ArticleThe Journal of cell biology1991
Regulated plasmalemmal expansion in nerve growth cones.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
- Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids.Journal of neurochemistry · 2026Article
- Review
- Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain.Scientific reports · 2019Article
- Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.Cell reports · 2018Article
- Regulation of dendrite growth and maintenance by exocytosis.Journal of cell science · 2015Article
- Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.Nature communications · 2014Article
- The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion.Nature cell biology · 2014Article
- Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.The EMBO journal · 2014Article
- Oxygen radicals elicit paralysis and collapse of spinal cord neuron growth cones upon exposure to proinflammatory cytokines.BioMed research international · 2014Article
- Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance.PloS one · 2013Article
- Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Single vesicle imaging indicates distinct modes of rapid membrane retrieval during nerve growth.BMC biology · 2012Article
- Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).PLoS biology · 2009Article
- Quantifying neurite growth mediated by interactions among secretory vesicles, microtubules, and actin networks.Biophysical journal · 2009Article
- Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones.Journal of cell science · 2008Article
- Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth.The Journal of cell biology · 2008Article
- Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- A novel pathway for presynaptic mitogen-activated kinase activation via AMPA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To study the mechanisms underlying plasmalemmal expansion in the nerve growth cone, a cell-free assay was developed to quantify membrane addition, using ligand binding and sealed growth cone particles isolated by subcellular fractionation from fetal rat brain. Exposed versus total binding sites of 125I-wheat germ agglutinin were measured in the absence or presence of saponin, respectively, after incubation with various agents. Ca2(+)-ionophore A23187 in the presence of Ca2+ increases the number of binding sites (Bmax) but does not change their affinity (KD), indicating that new receptors appear on the plasma membrane. Similarly, membrane depolarization by high K+ or veratridine significantly induces, in a Ca2(+)-dependent manner, the externalization of lectin binding sites from an internal pool. Morphometric analysis of isolated growth cones indicates that A23187 and high K+ treatment cause a significant reduction in a specific cytoplasmic membrane compartment, thus confirming the lectin labeling results and identifying the plasmalemmal precursor. The isolated growth cones take up gamma-amino-butyric acid and serotonin, but show no evidence for Ca2(+)-dependent transmitter release so that transmitter exocytosis is dissociated from plasmalemmal expansion. The data demonstrate that plasmalemmal expansion in the growth cone is a regulated process and identify an internal pool of precursor membrane.
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Registered trials
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