ArticleThe Journal of cell biology1991
Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 114 citations in OpenAlex.
- Revisiting the question: When is a centromere not a kinetochore?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer.Cancer research · 2024Article
- Article
- Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.Science translational medicine · 2014Article
- ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein.Chromosoma · 2008Article
- NuMA influences higher order chromatin organization in human mammary epithelium.Molecular biology of the cell · 2007Article
- NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.The Biochemical journal · 2005Article
- Centromere DNA, proteins and kinetochore assembly in vertebrate cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability.Molecular biology of the cell · 2003Article
- Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.Nucleic acids research · 2002Article
- Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells.Nucleic acids research · 2001Article
- CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells.The EMBO journal · 2001Article
- Regulation and localization of the Bloom syndrome protein in response to DNA damage.The Journal of cell biology · 2001Article
- CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.The Journal of cell biology · 2000Article
- Formation of spindle poles by dynein/dynactin-dependent transport of NuMA.The Journal of cell biology · 2000Article
- TIN2, a new regulator of telomere length in human cells.Nature genetics · 1999Article
- Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.The EMBO journal · 1999Article
- Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment.The Journal of cell biology · 1998Article
- NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation.The Journal of cell biology · 1998Article
- XMAP310: a Xenopus rescue-promoting factor localized to the mitotic spindle.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We describe the generation of 11 monoclonal antibodies that bind to the centromere/kinetochore region of human mitotic chromosomes. These antibodies were raised against mitotic chromosome scaffolds and screened for centromere/kinetochore binding by indirect immunofluorescence against purified chromosomes. Immunoblot analyses with these antibodies revealed that all of the antigens are greater than 200 kD and are components of nuclei, chromosomes, and/or chromosome scaffolds. Comparison of the immunolocalization of the antigens with that observed for the centromere-associated protein CENP-B revealed that each of these centromere/kinetochore proteins lies more peripherally to the DNA than does CENP-B. In cells normally progressing through the cell cycle, these antigens displayed four distinct patterns of centromere/kinetochore association, corresponding to a minimum of four novel centromere/kinetochore-associated proteins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.