ReviewSeminars in arthritis and rheumatism2010
The involvement of heat-shock proteins in the pathogenesis of autoimmune arthritis: a critical appraisal.
Review in Seminars in arthritis and rheumatism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response.The Journal of clinical investigation · 2024Article
- Quantitative Proteomic Analyses To Reveal the Key Features of Proteins in New Onset Ankylosing Spondylitis Patients.ACS omega · 2020Article
- Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis.Oncoimmunology · 2020Article
- Hsp65-ProducingFrontiers in immunology · 2020Article
- Heat Shock Proteins and Inflammasomes.International journal of molecular sciences · 2019Review
- Poncet's Disease in the Preclinical Phase of Rheumatoid Arthritis.Case reports in rheumatology · 2018Article
- Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis.Open access rheumatology : research and reviews · 2018Article
- Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced ArthritisFrontiers in immunology · 2017Article
- Vaccination with endosomal unknown epitopes produces therapeutic response in rheumatoid arthritis patients and modulates adjuvant arthritis of rats.Journal of translational medicine · 2016Article
- Expression levels of B7-H3 and TLT-2 in human oral squamous cell carcinoma.Oncology letters · 2015Article
- The danger model approach to the pathogenesis of the rheumatic diseases.Journal of immunology research · 2015Review
- Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.Cell stress & chaperones · 2014Article
- Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity.Human vaccines & immunotherapeutics · 2014Article
- Comparative antigen-induced gene expression profiles unveil novel aspects of susceptibility/resistance to adjuvant arthritis in rats.Molecular immunology · 2013Article
- Increased levels of IgG antibodies against human HSP60 in patients with spondyloarthritis.PloS one · 2013Article
- Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.Clinical and experimental immunology · 2013Review
- Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.International immunopharmacology · 2012Article
- Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.European journal of histochemistry : EJH · 2011Article
- The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge.Arthritis research & therapy · 2011Article
- Celastrus treatment modulates antigen-induced gene expression in lymphoid cells of arthritic rats.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo review the literature on the role of heat-shock proteins (HSPs) in the pathogenesis of autoimmune arthritis in animal models and patients with rheumatoid arthritis (RA).
methodsThe published literature in Medline (PubMed), including our published work on the cell-mediated as well as humoral immune response to various HSPs, was reviewed. Studies in the preclinical animal models of arthritis as well as RA were examined critically and the data are presented.
resultsIn experimental arthritis, disease induction by different arthritogenic stimuli, including an adjuvant, led to immune response to mycobacterial HSP65 (BHSP65). However, attempts to induce arthritis by a purified HSP have not met with success. There are several reports of a significant immune response to HSP65 in RA patients. However, the issue of cause and effect is difficult to address. Nevertheless, several studies in animal models and a couple of clinical trials in RA patients have shown the beneficial effect of HSPs against autoimmune arthritis.
conclusionsThere is a clear association between immune response to HSPs, particularly HSP65, and the initiation and propagation of autoimmune arthritis in experimental models. The correlation is relatively less convincing in RA patients. In both cases, the ability of HSPs to modulate arthritis offers support, albeit an indirect one, for the involvement of these antigens in the disease process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.