SynthesisThe Journal of pediatrics2010
Accounting for multiple births in neonatal and perinatal trials: systematic review and case study.
Synthesis in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review.Archives of disease in childhood. Fetal and neonatal edition · 2025Pooled it
- Correlation between neonatal outcomes of twins depends on the outcome: secondary analysis of twelve randomised controlled trials.BJOG : an international journal of obstetrics and gynaecology · 2018Pooled it
- A Digital Acceptance and Commitment Therapy and Education Intervention for Caregivers of Very Preterm Infants in the Neonatal Intensive Care Unit: Randomized Controlled Trial.JMIR mental health · 2026Trial
- Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial.PloS one · 2019Trial
- Sudden vs Pressure Wean From Nasal Continuous Positive Airway Pressure in Infants Born Before 32 Weeks of Gestation: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide.The Journal of pediatrics · 2016Trial
- Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.Trials · 2015Trial
- Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Article
- Causal inference in randomized trials with partial clustering.Clinical trials (London, England) · 2025Article
- Neonatal intermittent hypoxemia events are associated with later systemic hypertension.Pediatric research · 2025Article
- Sample Size Calculations for Partially Clustered Trials.Statistics in medicine · 2025Article
- Partially clustered designs for clinical trials: Unifying existing designs using consistent terminology.Clinical trials (London, England) · 2023Review
- Effect of Invasive Mechanical Ventilation at Birth on Lung Function Later in Childhood.Frontiers in pediatrics · 2022Article
- Systemic Inflammation in the First 2 Weeks after Birth as a Determinant of Physical Growth Outcomes in Hospitalized Infants with Extremely Low Gestational Age.The Journal of pediatrics · 2022Article
- Perinatal epidemiology: Issues, challenges, and potential solutions.Obstetric medicine · 2021Review
- Massachusetts' Parental Consent Law and Procedural Timing Among Adolescents Undergoing Abortion.Obstetrics and gynecology · 2019Observational
- Article
- Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network.Seminars in perinatology · 2016Article
- Analysis of Randomised Trials Including Multiple Births When Birth Size Is Informative.Paediatric and perinatal epidemiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesTo determine the prevalence in the neonatal literature of statistical approaches accounting for the unique clustering patterns of multiple births and to explore the sensitivity of an actual trial to several analytic approaches to multiples. STUDY
designA systematic review of recent perinatal trials assessed the prevalence of studies accounting for clustering of multiples. The Nitric Oxide to Prevent Chronic Lung Disease (NO CLD) trial served as a case study of the sensitivity of the outcome to several statistical strategies. We calculated odds ratios using nonclustered (logistic regression) and clustered (generalized estimating equations, multiple outputation) analyses.
resultsIn the systematic review, most studies did not describe the random assignment of twins and did not account for clustering. Of those studies that did, exclusion of multiples and generalized estimating equations were the most common strategies. The NO CLD study included 84 infants with a sibling enrolled in the study. Multiples were more likely than singletons to be white and were born to older mothers (P < .01). Analyses that accounted for clustering were statistically significant; analyses assuming independence were not.
conclusionsThe statistical approach to multiples can influence the odds ratio and width of confidence intervals, thereby affecting the interpretation of a study outcome. A minority of perinatal studies address this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.