ArticleBiological psychiatry2010
Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways.Molecular psychiatry · 2016Pooled it
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- Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025Review
- RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis.Frontiers in neuroscience · 2023Article
- Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- microRNAs and Gene-Environment Interactions in Autism: Effects of Prenatal Maternal Stress and theFrontiers in psychiatry · 2021Article
- Effects of stress on functional connectivity during verbal processing.Brain imaging and behavior · 2020Article
- The association between serotonin-related gene polymorphisms and susceptibility and early sertraline response in patients with panic disorder.BMC psychiatry · 2020Article
- Emerging Roles of RNA 3'-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders.Biomolecules · 2020Review
- Article
- Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.Frontiers in neuroscience · 2019Review
- Looking Beyond the 5-HTTLPR Polymorphism: Genetic and Epigenetic Layers of Regulation Affecting the Serotonin Transporter Gene Expression.Molecular neurobiology · 2017Review
- Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data.Genome biology and evolution · 2016Article
- Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.Biological psychology · 2015Article
- Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.Psychological medicine · 2015Article
- Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update.Translational psychiatry · 2015Review
- Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat.Frontiers in pharmacology · 2015Article
- Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism.Pharmacology, biochemistry, and behavior · 2014Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundGenetic markers in the serotonin transporter are associated with panic disorder (PD). The associated polymorphisms do not include the serotonin transporter-linked polymorphic region and display no obvious functional attributes. A common polymorphism (rs3813034) occurs in one of the two reported polyadenylation signals for the serotonin transporter and is in linkage disequilibrium with the PD-associated markers. If functional, rs3813034 might be the risk factor that explains the association of the serotonin transporter and PD.
methodsQuantitative polymerase chain reaction on human brain samples (n = 65) and lymphoblast cultures (n = 71) was used to test rs3813034 for effects on expression of the polyadenylation forms of the serotonin transporter. rs3813034 was also tested for association in a sample of PD cases (n = 307) and a control sample (n = 542) that has similar population structure.
resultsThe balance of the two polyadenylation forms of the serotonin transporter is associated with rs3813034 in brain (p < .001) and lymphoblasts (p < .001). The balance of the polyadenylation forms is also associated with gender in brain only (p < .05). Association testing of rs3813034 in PD identified a significant association (p = .0068) with a relative risk of 1.56 and 1.81 for the heterozygous and homozygous variant genotypes, respectively.
conclusionsrs3813034 is a functional polymorphism in the serotonin transporter that alters the balance of the two polyadenylation forms of the serotonin transporter. rs3813034 is a putative risk factor for PD and other behavioral disorders that involve dysregulation of serotonergic neurotransmission.
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