ArticleJournal of molecular biology2010
PCP consensus sequences of flaviviruses: correlating variance with vector competence and disease phenotype.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Lipid nanoparticles-mRNA based on the consensus sequences of avian coronavirus S1 and N genes protect animals against multiple viral infections.Journal of nanobiotechnology · 2025Article
- Sequences and Structures of Viral Proteins Linked to the Genomes (VPg) of RNA Viruses.Viruses · 2025Review
- Synthetic proteins for COVID-19 diagnostics.Peptides · 2021Article
- Article
- DGraph Clusters Flaviviruses and β-Coronaviruses According to Their Hosts, Disease Type, and Human Cell Receptors.Bioinformatics and biology insights · 2021Article
- D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors.bioRxiv : the preprint server for biology · 2020Article
- Polyglutamine Repeats in Viruses.Molecular neurobiology · 2019Review
- First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation.Parasites & vectors · 2019Article
- Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus.PLoS neglected tropical diseases · 2017Article
- Allosteric inhibitors of Coxsackie virus A24 RNA polymerase.Bioorganic & medicinal chemistry · 2016Article
- Sequence specificity for uridylylation of the viral peptide linked to the genome (VPg) of enteroviruses.Virology · 2015Article
- A High-Performance Multiplex Immunoassay for Serodiagnosis of Flavivirus-Associated Neurological Diseases in Horses.BioMed research international · 2015Article
- Identification of conserved motifs in the West Nile virus envelope essential for particle secretion.BMC microbiology · 2013Article
- Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins.BMC infectious diseases · 2013Article
- Dengue virus type 3 adaptive changes during epidemics in São Jose de Rio Preto, Brazil, 2006-2007.PloS one · 2013Article
- Simplifying complex sequence information: a PCP-consensus protein binds antibodies against all four Dengue serotypes.Vaccine · 2012Article
- Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals.BMC bioinformatics · 2012Article
- NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU).Peptides · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundComputational methods are needed to design multivalent vaccines against flaviviruses (FVs) such as the West Nile virus or the dengue virus (DENV).
objectiveWe aimed to use physicochemical property (PCP) consensus sequences of FV strains to delineate conserved motifs, areas of maximum variability, and specific loci that correlate with arthropod vector, serotype, and disease severity.
methodsPCP consensus sequences for 27 species were prepared from 928 annotated sequences catalogued in Flavitrack. Alignments of these correlated well with the known structures of the NS3 protease domain and envelope (E) proteins. The PCPMer suite was used to identify motifs common to all FVs. Areas of PCP variability that correlated with phenotype were plotted on the structures.
resultsDespite considerable diversity at the amino acid level, PCPs for both proteins were well conserved throughout the FVs. A series of insertions in E separated tick- from mosquito-borne viruses and all arthropod-borne viruses from isolates with no known vector or directly from insects. Comparison of a PCP consensus sequence of E derived from 600 DENV strains (DENV600) with individual ones for DENV1-DENV4 showed that most major serotype-specific variation occurs near these insertions. The DENV600 differed from one prepared from eight hemorrhagic or fatal strains from four DENV serotypes at only three positions, two of which overlap known escape mutant sites.
conclusionsComparing consensus sequences showed that substantial changes occur in only a few areas of the E protein. PCP consensus sequences can contribute to the design of multivalent vaccines.
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