ArticleBioconjugate chemistry2010
Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery.
Article in Bioconjugate chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- PEGylation Enhances Colloidal Stability and Promotes Ligand-Mediated Targeting of LAF-Xenopeptide mRNA Complexes.Polymers · 2025Article
- Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2024Article
- Solid-phase supported design of carriers for therapeutic nucleic acid delivery.Bioscience reports · 2017Review
- Covalent nano delivery systems for selective imaging and treatment of brain tumors.Advanced drug delivery reviews · 2017Review
- Reducible, dibromomaleimide-linked polymers for gene delivery.Biomaterials science · 2015Article
- Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity.Journal of the American Chemical Society · 2014Article
- Polymer-peptide delivery platforms: effect of oligopeptide orientation on polymer-based DNA delivery.Biomacromolecules · 2014Article
- Engineering biodegradable and multifunctional peptide-based polymers for gene delivery.Journal of biological engineering · 2013Article
- A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells.Angewandte Chemie (International ed. in English) · 2013Article
- Influence of histidine incorporation on buffer capacity and gene transfection efficiency of HPMA-co-oligolysine brush polymers.Biomacromolecules · 2013Article
- A bioreducible polymer for efficient delivery of Fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis.Angewandte Chemie (International ed. in English) · 2012Article
- Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery.International journal of pharmaceutics · 2012Article
- Synthesis of water-soluble poly(α-hydroxy acids) from living ring-opening polymerization of O-benzyl-L-serine carboxyanhydrides.ACS macro letters · 2012Article
- Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus.Biomaterials · 2011Article
- HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Multiplexed supramolecular self-assembly for non-viral gene delivery.Biomaterials · 2010Article
- Synthesis of statistical copolymers containing multiple functional peptides for nucleic Acid delivery.Biomacromolecules · 2010Article
- Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model.Molecular pharmaceutics · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bioactive peptides, including DNA-binding, endosomal release, and cell targeting peptides, have been integrated into synthetic gene carriers to improve delivery efficiency by enabling the vectors to overcome barriers to gene delivery. Our overall goal is to develop multifunctional, peptide-based polymers that incorporate motifs to condense DNA and facilitate sequential trafficking steps. One approach is to polymerize vinyl-terminated peptides by radical polymerization. In this work, cationic oligolysine peptides were designed to contain vinyl termini with internal reducible linkers. These peptides were copolymerized with HPMA to form biodegradable, DNA-condensing copolymers for gene delivery. The polymerization conditions were optimized by varying the initiator to monomer ratios, macromonomer to comonomer ratios, and reactant concentrations. The synthesized copolymers were shown to possess several important properties required for in vivo gene delivery applications, including (i) efficient DNA binding and condensation, (ii) the ability to stabilize particles against salt-induced aggregation, (iii) the ability to resist extracellular polyplex unpackaging, (iv) biocompatibility and the potential to be degraded into nontoxic components after cellular uptake, and (v) efficient delivery of plasmid to cultured cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.