Trial reportEuropean journal of applied physiology2010
HPA and SAS responses to increasing core temperature during uncompensable exertional heat stress in trained and untrained males.
Trial report in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Trial
- Peripheral markers of central fatigue in trained and untrained during uncompensable heat stress.European journal of applied physiology · 2012Trial
- Does summer in a humid continental climate elicit an acclimatization of human thermoregulatory responses?European journal of applied physiology · 2011Trial
- Influence of aerobic fitness on gastrointestinal barrier integrity and microbial translocation following a fixed-intensity military exertional heat stress test.European journal of applied physiology · 2020Article
- Individual Responses to Heat Stress: Implications for Hyperthermia and Physical Work Capacity.Frontiers in physiology · 2020Review
- Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review.Frontiers in physiology · 2018Review
- Heart rate variability and plasma nephrines in the evaluation of heat acclimatisation status.European journal of applied physiology · 2018Article
- Heat and Dehydration Additively Enhance Cardiovascular Outcomes following Orthostatically-Stressful Calisthenics Exercise.Frontiers in physiology · 2017Article
- Circadian disturbance and idiopathic central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Heat stress and dehydration in adapting for performance: Good, bad, both, or neither?Temperature (Austin, Tex.) · 2016Review
- Reproductive hormones and interleukin-6 in serious leisure male athletes.European journal of applied physiology · 2012Article
- Effects of heat stress on endocrine functions & behaviour in the pre-pubertal rat.The Indian journal of medical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increases in core temperature (T (c)) augment stress hormones and neurotransmitters; however, the effect of different T (c) tolerated with varying fitness levels during uncompensable exertional heat stress (EHS) is unclear. The purpose was to examine the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenomedullary system (SAS) responses during uncompensable EHS in trained (TR) versus untrained (UT) males. Twelve TR and 11 UT (VO(2peak) = 70 +/-2 and 50 +/- 1 mL kg of lean body mass(-1) min(-1)) walked on a treadmill to exhaustion (EXH) in 40 degrees C (dry), dressed in protective clothing. PRE and 0.5 degrees C T (c) increments from 38.0-40.0 degrees C/EXH venous blood was obtained. Cortisol responded to absolute thermal strain, increasing throughout EHS and independent of fitness. Adrenocorticotropic Hormone, Norepinephrine, and Dehydroepiandrosterone-Sulphate responded to relative thermal strain with similar EXH values, despite higher T (c) tolerated for TR (39.7 degrees C) than UT (39.0 degrees C). Epinephrine, Growth Hormone (GH), and Aldosterone increased initially, with a plateau above 38.5 degrees C T (c). Findings demonstrate the complexity of the HPA axis, SAS, and T (c) relationship, with the stress pathways responding largely to relative thermal strain, although some hormones exhibited a clamping response likely as a protective mechanism. For the TR, evidence existed for a reduced pituitary sensitivity to glucocorticoids and the amplified GH may have contributed to their greater T (c) tolerated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.