ReviewPediatric surgery international2010
Microecology, intestinal epithelial barrier and necrotizing enterocolitis.
Review in Pediatric surgery international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- IS -94INS/DELATTG POLYMORPHISM IN THE NUCLEAR FACTOR KAPPA-B1 GENE (NFKB1) ASSOCIATED WITH NECROTIZING ENTEROCOLITIS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Article
- Analysis of clinical features of neonates with congenital heart disease who develop necrotizing enterocolitis: a retrospective case-control study.Annals of translational medicine · 2022Article
- Article
- Impact of ProbioticFrontiers in pediatrics · 2021Article
- Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity.Virulence · 2018Review
- Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats.PloS one · 2017Article
- Can probiotics modulate human disease by impacting intestinal barrier function?The British journal of nutrition · 2017Review
- The Eukaryotic Microbiome: Origins and Implications for Fetal and Neonatal Life.Frontiers in pediatrics · 2016Review
- Article
- Necrotizing enterocolitis in infants with ductal-dependent congenital heart disease.American journal of perinatology · 2015Article
- Identification of Potential Biomarkers for Gut Barrier Failure in Broiler Chickens.Frontiers in veterinary science · 2015Article
- Pathogenesis of necrotizing enterocolitis: modeling the innate immune response.The American journal of pathology · 2015Review
- A clinical perspective of necrotizing enterocolitis: past, present, and future.Clinics in perinatology · 2013Review
- Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs.PloS one · 2013Article
- Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses.Pediatric research · 2012Article
- Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model.Surgical infections · 2012Article
- Lysozyme transgenic goats' milk positively impacts intestinal cytokine expression and morphology.Transgenic research · 2011Article
- Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis.Pediatric surgery international · 2011Article
- Probiotics and prebiotics for the prevention of necrotizing enterocolitis.Current infectious disease reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Soon after birth, the neonatal intestine is confronted with a massive antigenic challenge of microbial colonization. Microbial signals are required for maturation of several physiological, anatomical, and biochemical functions of intestinal epithelial barrier (IEB) after birth. Commensal bacteria regulate intestinal innate and adaptive immunity and provide stimuli for ongoing repair and restitution of IEB. Colonization by pathogenic bacteria and/or dysmature response to microbial stimuli can result in flagrant inflammatory response as seen in necrotizing enterocolitis (NEC). Characterized by inflammation and hemorrhagic-ischemic necrosis, NEC is a devastating complication of prematurity. Although there is evidence that both prematurity and presence of bacteria, are proven contributing factors to the pathogenesis of NEC, the molecular mechanisms involved in IEB dysfunction associated with NEC have begun to emerge only recently. The metagenomic advances in the field of intestinal microecology are providing insight into the factors that are required for establishment of commensal bacteria that appear to provide protection against intestinal inflammation and NEC. Perturbations in achieving colonization by commensal bacteria such as premature birth or hospitalization in intensive care nursery can result in dysfunction of IEB and NEC. In this article, microbial modulation of functions of IEB and its relationship with barrier dysfunction and NEC are described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.