Evidence map›Paper›PMID 19967137›Full record

ReviewThrombosis and haemostasis2009

Infection of the endothelium by members of the order Rickettsiales.

Gustavo Valbuena, David H Walker

Open access · greenAbstract readReview
In one paragraph

Review in Thrombosis and haemostasis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Infection and immunity · 2024
    Article
  6. Article
  7. Article
  8. Epidemic retinitis during the COVID-19 pandemic.Indian journal of ophthalmology · 2023
    Observational
  9. Leukocytoclastic Vasculitis: A peculiar presentation of scrub typhus.Sultan Qaboos University medical journal · 2023
    Article
  10. Article
  11. An Update on the Laboratory Diagnosis ofPathogens (Basel, Switzerland) · 2021
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Endothelial Activation inFrontiers in cellular and infection microbiology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gustavo ValbuenaDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0609, USA. gvalbuen@utmb.edu
David H Walker
The University of Texas Medical Branch at Galveston · US

Funding

WRCE Nonhuman Primate CoreU54AI057156 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WALKER, DAVID H · 2003 to 2013
$102.6M
SPOTTED FEVER RICKETTSIAL ANTIGENSR01AI021242 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WALKER, DAVID H · 1985 to 2013
$5.2M
Role of the endothelium in the T cell-mediated anti-rickettsial immune responseR21AI069171 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI VALBUENA, GUSTAVO · 2007 to 2009
$633k
NIAID NIH HHS 1R21AI069171NIAID NIH HHS R01 AI021242NIAID NIH HHS R21 AI069171NIAID NIH HHS U54 AI057156PHS HHS R01AL21242
6 · The paper itself

Abstract

The vascular endothelium is the main target of a limited number of infectious agents, Rickettsia, Ehrlichia ruminantium, and Orientia tsutsugamushi are among them. These arthropod-transmitted obligately-intracellular bacteria cause serious systemic diseases that are not infrequently lethal. In this review, we discuss the bacterial biology, vector biology, and clinical aspects of these conditions with particular emphasis on the interactions of these bacteria with the vascular endothelium and how it responds to intracellular infection. The study of these bacteria in relevant in vivo models is likely to offer new insights into the physiology of the endothelium that have not been revealed by other models.

Indexed as

AnimalsArthropod VectorsChemokinesCytokinesEndothelium, VascularHost-Pathogen InteractionsHumansRickettsiaceaeRickettsiaceae InfectionsChemokinesCytokines

Identifiers

PMID19967137
PMCPMC2913309
OpenAlexW2015009744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.