ArticleThe Korean journal of parasitology2009
Antigenemia and specific IgM and IgG antibody responses in rabbits infected with Toxoplasma gondii.
Article in The Korean journal of parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Characterization of Excretory-Secretory Antigens of Toxoplasma gondii in the Acute and Chronic Phase of Toxoplasmosis in a Murine Model.Acta parasitologica · 2025Article
- Isolation and genetic characterization ofCurrent research in parasitology & vector-borne diseases · 2024Article
- Epidemiological and Public Health Significance ofMicroorganisms · 2021Review
- Assessment of antigenic specificity of polyclonal antisera raised againstVeterinary and animal science · 2020Article
- Prevalence of Toxoplasma gondii infection in rabbits of Korea by serological tests and nested polymerase chain reaction.The Journal of veterinary medical science · 2013Article
- The merits of designed ELISA avidity kit in detection of Toxoplasma gondii IgG antibody in laboratory conditions.Tropical parasitology · 2013Article
- Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts.Parasites & vectors · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this experiment, the correlation between antigenemia and specific antibody responses in Toxoplasma gondii-infected rabbits was assessed. We injected 1,000 T. gondii tachyzoites (RH) subcutaneously into 5 rabbits. Parasitemia, circulating antigens, and IgM and IgG antibody titers in blood were tested by ELISA and immunoblot. For detection of parasitemia, mice were injected with blood from rabbits infected with T. gondii and mice died between days 2 and 10 post-infection (PI). Circulating antigens were detected early on day 2 PI, and the titers increased from day 4 PI and peaked on day 12 PI. Anti-Toxoplasma IgM antibody titers increased on day 6 PI and peaked on days 14-16 PI. IgG was detected from day 10 PI, and the titers increased continuously during the experiment. The antigenic protein patterns differed during the infection period, and the number of bands increased with ongoing infection by the immunoblot analysis. These result indicated that Toxoplasma circulating antigens during acute toxoplasmosis are closely related to the presence of parasites in blood. Also, the circulating antigen levels were closely correlated with IgM titers, but not with IgG titers. Therefore, co-detection of circulating antigens with IgM antibodies may improve the reliability of the diagnosis of acute toxoplasmosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.