ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2008
Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1Bbeta Protein.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- SNX17 Mediates Dendritic Spine Maturation via p140Cap.Molecular neurobiology · 2024Article
- Myosin VI contributes to malignant proliferation of human glioma cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1).The Journal of biological chemistry · 2014Article
- Human papillomavirus L2 facilitates viral escape from late endosomes via sorting nexin 17.Traffic (Copenhagen, Denmark) · 2012Article
- PX-FERM proteins: A link between endosomal trafficking and signaling?Small GTPases · 2011Article
- Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
KIF1Bbeta is a member of the Kinesin superfamily proteins (KIFs), which are microtubule-dependent molecular motors that are involved in various intracellular organellar transport processes. KIF1Bbeta is not restricted to neuronal systems, however, is widely expressed in other tissues, even though the function of KIF1Bbeta is still unclear. To elucidate the KIF1Bbeta-binding proteins in non-neuronal cells, we used the yeast two-hybrid system, and found a specific interaction of KIF1Bbeta and the sorting nexin (SNX) 17. The C-terminal region of SNX17 is required for the binding with KIF1Bbeta. SNX17 protein bound to the specific region of KIF1Bbeta (813-916. aa), but not to other kinesin family members. In addition, this specific interaction was also observed in the Glutathione S-transferase pull-down assay. An antibody to SNX17 specifically co-immunoprecipitated KIF1Bbeta associated with SNX17 from mouse brain extracts. These results suggest that SNX17 might be involved in the KIF1Bbeta-mediated transport as a KIF1Bbeta adaptor protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.