ArticleAmerican journal of translational research2009
Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
Article in American journal of translational research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies.PeerJ · 2023Pooled it
- Review
- Catfish Epidermal Preparation Accelerates Healing of Damaged Nerve in a Sciatic Nerve Crush Injury Rat Model.Frontiers in pharmacology · 2021Article
- Research Progress of the Antiviral Bioactivities of Natural Flavonoids.Natural products and bioprospecting · 2020Review
- Green tea catechins inhibit microglial activation which prevents the development of neurological disorders.Neural regeneration research · 2020Review
- A Review of the Antiviral Role of Green Tea Catechins.Molecules (Basel, Switzerland) · 2017Review
- Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology.Antioxidants & redox signaling · 2015Review
- (-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury.Journal of neurotrauma · 2015Article
- MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the glutathione cycle.American journal of translational research · 2015Article
- Cognitive Consequences of Aging with HIV: Implications for Neuroplasticity and Rehabilitation.Topics in geriatric rehabilitation · 2014Article
- The role of neuroplasticity and cognitive reserve in aging with HIV: recommendations for cognitive protection and rehabilitation.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2013Article
- Prevention, Rehabilitation, and Mitigation Strategies of Cognitive Deficits in Aging with HIV: Implications for Practice and Research.ISRN nursing · 2013Article
- The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention.Journal of neuroinflammation · 2012Review
- HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND.American journal of translational research · 2012Article
- Assessing and treating forgetfulness and cognitive problems in adults with HIV.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In the current era of antiretroviral treatment, the prevalence of HIV-associated dementia is on the rise. Many past works have associated inflammation and neuronal loss with cognitive deficits inherent to the syndrome. Importantly, HIV-1 induced astrogliosis has been shown to play a central role in this process. Here we examined the effect of green tea derived (-)-epigallocatechin-3-gallate (EGCG) food supplementation for its ability to modulate GFAP expression and neuronal loss in an HIV-1 Tat transgenic mouse model whose expression was controlled by a brain specific doxycycline promoter. By immunohistochemistry we found that EGCG (300mg/kg/day) dramatically reduced astrogliosis as demonstrated by GFAP expression. This was accompanied by a mild reduction in activated microglia by Iba-1 staining and significant reduction in neuronal loss through apoptosis as demonstrated by MAP2 staining and Western blot analysis respectively. Future studies will be required to determine intracellular mechanism involved in EGCG mediated downregulation of GFAP and associated astrocytosis and neuronal loss.
Indexed as
Identifiers
19966940PMC2776283W96904577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.