ArticleJournal of bacteriology2010
Glycerol is metabolized in a complex and strain-dependent manner in Enterococcus faecalis.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Cellodextrin Metabolism and Phosphotransferase System-Catalyzed Uptake in Enterococcus faecalis.Molecular microbiology · 2025Article
- Role of sortase-assembled Ebp pili inMicrobiology spectrum · 2025Article
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- Microbial transcriptional responses to host diet maintain gut microbiome homeostasis in the American cockroach.bioRxiv : the preprint server for biology · 2024Article
- Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide.Journal of bacteriology · 2024Article
- Article
- Roles of flavoprotein oxidase and the exogenous heme- and quinone-dependent respiratory chain in lactic acid bacteria.Bioscience of microbiota, food and health · 2024Review
- Glycerol metabolism supports oral commensal interactions.The ISME journal · 2023Article
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- Methods for the Development of Recombinant Microorganisms for the Production of Natural Products.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Gut microbiota-mediated tributyltin-induced metabolic disorder in rats.RSC advances · 2020Article
- Article
- Enterococcus faecalis Manganese Exporter MntE Alleviates Manganese Toxicity and Is Required for Mouse Gastrointestinal Colonization.Infection and immunity · 2020Article
- Dietary Emulsifiers Alter Composition and Activity of the Human Gut MicrobiotaFrontiers in microbiology · 2020Article
- Adaptive Laboratory Evolution ofInternational journal of molecular sciences · 2019Article
- Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.Microbiology and molecular biology reviews : MMBR · 2019Review
- Lactic acid fermentation is the main aerobic metabolic pathway in Enterococcus faecalis metabolizing a high concentration of glycerol.Applied microbiology and biotechnology · 2018Article
- Transcriptome Changes ofFrontiers in microbiology · 2018Article
- Enzymes Required for Maltodextrin Catabolism in Enterococcus faecalis Exhibit Novel Activities.Applied and environmental microbiology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococcus faecalis is equipped with two pathways of glycerol dissimilation. Glycerol can either first be phosphorylated by glycerol kinase and then oxidized by glycerol-3-phosphate oxidase (the glpK pathway) or first be oxidized by glycerol dehydrogenase and then phosphorylated by dihydroxyacetone kinase (the dhaK pathway). Both pathways lead to the formation of dihydroxyacetone phosphate, an intermediate of glycolysis. It was assumed that the glpK pathway operates during aerobiosis and that the dhaK pathway operates under anaerobic conditions. Because this had not been analyzed by a genetic study, we constructed mutants of strain JH2-2 affected in both pathways. The growth of these mutants on glycerol under aerobic and anaerobic conditions was monitored. In contrast to the former model, results strongly suggest that glycerol is catabolized simultaneously by both pathways in the E. faecalis JH2-2 strain in the presence of oxygen. In accordance with the former model, glycerol is metabolized by the dhaK pathway under anaerobic conditions. Comparison of different E. faecalis isolates revealed an impressive diversity of growth behaviors on glycerol. Analysis by BLAST searching and real-time reverse transcriptase PCR revealed that this diversity is based not on different gene contents but rather on differences in gene expression. Some strains used preferentially the glpK pathway whereas others probably exclusively the dhaK pathway under aerobic conditions. Our results demonstrate that the species E. faecalis cannot be represented by only one model of aerobic glycerol catabolism.
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