ArticleArteriosclerosis, thrombosis, and vascular biology2010
Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Role of non-coding variants in cardiovascular disease.Journal of cellular and molecular medicine · 2023Review
- Article
- Genetics of Familial Combined Hyperlipidemia (FCHL) Disorder: An Update.Biochemical genetics · 2022Review
- Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Genetic and environmental determinants of the susceptibility of Amerindian derived populations for having hypertriglyceridemia.Metabolism: clinical and experimental · 2014Review
- Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.Journal of medical genetics · 2013Article
- ASPic-GeneID: a lightweight pipeline for gene prediction and alternative isoforms detection.BioMed research international · 2013Article
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.The Journal of clinical investigation · 2011Article
- Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeAlthough the Mexican population has a high predisposition to dyslipidemias and premature coronary artery disease, this population is underinvestigated for the genetic factors conferring the high susceptibility. This study attempted to determine these genetic factors. METHODS AND
resultsFirst, we investigated apolipoprotein B (apoB) levels in Mexican extended families with familial combined hyperlipidemia using a two-step testing strategy. In the screening step, we screened 5721 single-nucleotide polymorphisms (SNPs) for linkage signals with apoB. In the test step, we analyzed the 130 SNPs residing in regions of suggestive linkage signals for association with apoB. We identified significant associations with two SNPs (ie, rs1424032 [P=6.07x10(-6)] and rs1349411 [P=2.72x10(-4)]) that surpassed the significance level for the number of tests performed in the test step (P<3.84x10(-4)). Second, these SNPs were tested for replication in Mexican hyperlipidemic case-control samples. The same risk alleles as in the families with familial combined hyperlipidemia were significantly associated (P<0.05) with apoB in the case-control samples. The rs1349411 resides near the apoB messenger RNA editing enzyme (APOBEC1) involved in the processing of APOB messenger RNA in the small intestine. The rs1424032 resides in a highly conserved noncoding region predicted to function as a regulatory element.
conclusionsWe identified two novel variants, rs1349411 and rs1424032, for serum apoB levels in Mexicans.
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