ArticleArteriosclerosis, thrombosis, and vascular biology2010
Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- EGR1 regulates degranulation and mediator release in C48/80-induced pseudo-allergic reactions.Immunologic research · 2026Article
- Egr‑1 promotes the proliferation and migration of vascular smooth muscle cells by transcriptionally activating Egr‑2 in arteriovenous fistulas.International journal of molecular medicine · 2025Article
- Article
- Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging Predicts Vein Wall Scarring and Statin Benefit in Murine Venous Thrombosis.Circulation. Cardiovascular imaging · 2021Article
- Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor-mediated mRNA decay.Science advances · 2021Article
- Egr1 deficiency disrupts dynamic equilibrium of chondrocyte extracellular matrix through PPARγ/RUNX2 signaling pathways.American journal of translational research · 2018Article
- Endovascular retrieval of Greenfield IVC filters 13 and 19 years post placement without major complication.Journal of radiology case reports · 2017Article
- Early growth response-1 in the pathogenesis of cardiovascular disease.Journal of molecular medicine (Berlin, Germany) · 2016Review
- DT(270-326) , a Truncated Diphtheria Toxin, Increases Blood-Tumor Barrier Permeability by Upregulating the Expression of Caveolin-1.CNS neuroscience & therapeutics · 2016Article
- Clinicopathological implications ofOncology letters · 2016Article
- EGR1 Regulates Transcription Downstream of Mechanical Signals during Tendon Formation and Healing.PloS one · 2016Article
- EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription.Scientific reports · 2015Article
- CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts.Cardiovascular research · 2015Article
- Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima.Kidney international · 2015Article
- Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection.The Journal of pathology · 2015Article
- Pulmonary hypertension caused by pulmonary venous hypertension.Pulmonary circulation · 2014Review
- Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction.PloS one · 2014Article
- Transcription factor EGR1 directs tendon differentiation and promotes tendon repair.The Journal of clinical investigation · 2013Article
- Milk yield responses to changes in milking frequency during early lactation are associated with coordinated and persistent changes in mammary gene expression.BMC genomics · 2013Article
- Early growth response protein 1 promotes restenosis by upregulating intercellular adhesion molecule-1 in vein graft.Oxidative medicine and cellular longevity · 2013Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveVein grafts in a coronary bypass or a hemodialysis access often develop obliterative growth of the neointima. We previously reported that the mechanical stretch-activated insulin-like growth factor-1 receptor (IGF-1/IGF-1R) pathway plays an important role in this remodeling. However, the transcriptional mechanism(s) regulating IGF-1R expression and neointima formation have not been identified. METHODS AND
resultsDeletion and site-specific mutagenesis analysis of IGF-1R promoter identified that the minimal mechano-responsive promoter element (-270--130) contains 2 consensus sequences for binding of early growth reponse-1 (Egr-1) transcriptional factor. Mechanical stretch stimulated both Egr-1 mRNA (4.6-fold) and protein (5.2-fold) in vascular smooth muscle cells. Interposition of a vein into an artery increased Egr-1 mRNA (7.8+/-2.6-fold vs sham). In vascular smooth muscle cells isolated from Egr-1 knockout mice, mechanical stretch could not increase IGF-1R, and vascular smooth muscle cells proliferation was decreased by 47% compared to wild-type cells. Importantly, the neointima area was reduced by at least 50%, and the lumen-to-media ratio increased by 55% in vein grafts of Egr-1 knockout mice compared with results of wild-type mice.
conclusionsEgr-1 is a mechano-sensitive transcriptional factor that stimulates IGF-1R transcription, resulting in vascular remodeling of vein grafts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.