ArticleArteriosclerosis, thrombosis, and vascular biology2010
L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- High-density lipoprotein: a biomarker and therapeutic target in sepsis.Critical care (London, England) · 2025Review
- Peptides as Therapeutic Agents for Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- APOA1: a Protein with Multiple Therapeutic Functions.Current atherosclerosis reports · 2021Review
- The Apolipoprotein A-I Mimetic L-4F Attenuates Monocyte Activation and Adverse Cardiac Remodeling after Myocardial Infarction.International journal of molecular sciences · 2020Article
- Intravenous toxicity and toxicokinetics of an HDL mimetic, Fx-5A peptide complex, in cynomolgus monkeys.Regulatory toxicology and pharmacology : RTP · 2018Article
- High-density lipoprotein mimetics: promises and challenges.The Biochemical journal · 2015Review
- Small lipidated anti-obesity compounds derived from neuromedin U.European journal of medicinal chemistry · 2015Article
- Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine.Environmental health perspectives · 2015Article
- High-density lipoprotein: a novel target for antirestenosis therapy.Clinical and translational science · 2014Review
- Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.Circulation · 2014Article
- APOε4 is associated with enhanced in vivo innate immune responses in human subjects.The Journal of allergy and clinical immunology · 2014Article
- Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.PloS one · 2014Article
- Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice.Journal of lipid research · 2013Article
- Mild hypercholesterolemia blunts the proinflammatory and prothrombotic effects of hypertension on the cerebral microcirculation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice.Journal of lipid research · 2012Article
- Novel HDL-directed pharmacotherapeutic strategies.Nature reviews. Cardiology · 2011Review
- Apolipoprotein mimetic peptides: Mechanisms of action as anti-atherogenic agents.Pharmacology & therapeutics · 2011Article
- Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteins.Circulation journal : official journal of the Japanese Circulation Society · 2011Review
- Regulation of platelet function by class B scavenger receptors in hyperlipidemia.Arteriosclerosis, thrombosis, and vascular biology · 2010Review
- 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice.The Journal of pharmacology and experimental therapeutics · 2010Article
Corrections and comments
- Erratum issuedDosage error in article text
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledBackground and Purpose- Hyperlipidemia is associated with platelet hyperreactivity. We hypothesized that L-4F, an apolipoprotein A-I mimetic peptide, would inhibit platelet aggregation in hyperlipidemic mice. METHODS AND
resultsInjecting L-4F into apolipoprotein E (apoE)-null and low-density lipoprotein receptor-null mice resulted in a significant reduction in platelet aggregation in response to agonists; however, there was no reduction in platelet aggregation after injection of L-4F into wild-type (WT) mice. Consistent with these results, injection of L-4F into apoE-null mice prolonged bleeding time; the same result was not found in WT mice. Incubating L-4F in vitro with apoE-null platelet-rich plasma also resulted in decreased platelet aggregation. However, incubating washed platelets from either apoE-null or WT mice with L-4F did not alter aggregation. Compared with WT mice, unstimulated platelets from apoE-null mice contained significantly more 12-hydroxy 5,8,10,14-eicosatetraenoic acid, thromboxane A(2), and prostaglandins D(2) and E(2). In response to agonists, platelets from L-4F-treated apoE-null mice formed significantly less thromboxane A(2), prostaglandins D(2) and E(2), and 12-hydroxy 5,8,10,14-eicosatetraenoic acid.
conclusionsBy binding plasma-oxidized lipids that cause platelet hyperreactivity in hyperlipidemic mice, L-4F decreases platelet aggregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.