ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2009
Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- Multiscale anisotropy analysis of second-harmonic generation collagen imaging of human pancreatic cancer.Frontiers in oncology · 2022Article
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- Recent Advancements in Optical Harmonic Generation Microscopy: Applications and Perspectives.BME frontiers · 2021Review
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- Identifying Two Common Types of Breast Benign Diseases Based on Multiphoton Microscopy.Scanning · 2018Article
- Cellular imaging in rheumatic diseases.Nature reviews. Rheumatology · 2015Review
- Applications of second-harmonic generation imaging microscopy in ovarian and breast cancer.Perspectives in medicinal chemistry · 2015Article
- Automated quantification of aligned collagen for human breast carcinoma prognosis.Journal of pathology informatics · 2014Article
- Three dimensional multiphoton imaging of fresh and whole mount developing mouse mammary glands.BMC cancer · 2013Article
- Optical biomarkers of serous and mucinous human ovarian tumor assessed with nonlinear optics microscopies.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, new non-invasive imaging methods have been developed and applied to cellular and animal mammary models that have enabled breast cancer researchers to track key players and events in mammary metastasis. Noninvasive nonlinear optical methods such as multiphoton laser scanning microscopy (MPLSM), Fluorescence Lifetime Microscopy (FLIM) and second harmonic generation (SHG) imaging provide an unrivaled ability for obtaining high-resolution images from deep within tissue that can be exploited in the quest to understand breast cancer progression. These optical methods can add greatly to our knowledge of cancer progression by allowing key processes to be non-invasively imaged such as metabolism (on the basis of free and bound NADH detection via FLIM) and interactions with the extracellular matrix (SHG imaging of collagen). In this short application note we present a survey of our latest optical and computational efforts to study intrinsic fluorescence in breast cancer models. In particular we present the latest development in our SLIM Plotter application, an open source visualization program for interactive visualization and inspection of combined spectral lifetime (SLIM) data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.