ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2009
Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical stimulation.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Effects of electrical stimulation on the cardiogenic differentiation of mesenchymal stem cells: A systematic review.Cytotechnology · 2026Review
- The Bionic Interface: Considering the Material Mediated Electrical Stimulation of Stem Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Article
- Electrical Stimulation Therapy - Dedicated to the Perfect Plastic Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advancing Chronic Wound Healing through Electrical Stimulation and Adipose-Derived Stem Cells.Advanced healthcare materials · 2025Review
- Development and application of a novel multi-channel in vitro electrical stimulator for cellular research.BMC biomedical engineering · 2025Article
- Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity.BMC veterinary research · 2025Article
- Cell shape and orientation control galvanotactic accuracy.Soft matter · 2024Article
- Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation.Bioengineering & translational medicine · 2024Article
- Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling.Journal of biomaterials applications · 2023Review
- Effects of Varied Stimulation Parameters on Adipose-Derived Stem Cell Response to Low-Level Electrical Fields.Annals of biomedical engineering · 2021Article
- Electric field stimulation for tissue engineering applications.BMC biomedical engineering · 2021Review
- Redox Polymers for Tissue Engineering.Frontiers in medical technology · 2021Review
- Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration.Bioactive materials · 2020Review
- Electrical stimulation in bone tissue engineering treatments.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Review
- Changing Expression Profiles and Inclination to Competing Endogenous RNA Networks on MAPK Signaling Pathways of Human Adipose-Derived Stem Cells in a Direct Current Electric Field.BioMed research international · 2020Article
- A General Theoretical Framework to Study the Influence of Electrical Fields on Mesenchymal Stem Cells.Frontiers in bioengineering and biotechnology · 2020Article
- Direct electrical stimulation enhances osteogenesis by inducing Bmp2 and Spp1 expressions from macrophages and preosteoblasts.Biotechnology and bioengineering · 2019Article
- Electrical stimulation promotes the angiogenic potential of adipose-derived stem cells.Scientific reports · 2019Article
- Src activation decouples cell division orientation from cell geometry in mammalian cells.Biomaterials · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
In vivo, direct current electric fields are present during embryonic development and wound healing. In vitro, direct current (DC) electric fields induce directional cell migration and elongation. For the first time, we demonstrate that cultured human adipose tissue-derived stem cells (hASCs) respond to the presence of direct-current electric fields. Cells were stimulated for 2-4 hours with DC electric fields of 6 V/cm that were similar to those encountered in vivo post-injury. Upon stimulation, hASCs were observed to elongate and align perpendicularly to the applied electric field, disassemble gap junctions, and upregulate the expression of genes for connexin-43, thrombomodulin, vascular endothelial growth factor, and fibroblast growth factor. In separate related studies, human epicardial fat-derived stem cells (heASCs) were also observed to align and elongate. It is interesting that the morphological and phenotypic characteristics of mesenchymal stem cells derived both from liposuction aspirates and from cardiac fat can be modulated by direct current electric fields. In further studies, we will quantify the effects of the electrical fields in the context of wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.