ArticleProceedings of the National Academy of Sciences of the United States of America1991
Inducible proteins binding to the murine thymidine kinase promoter in late G1/S phase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 79 citations in OpenAlex.
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- Productive infection and bICP0 early promoter activity of bovine herpesvirus 1 are stimulated by E2F1.Journal of virology · 2010Article
- Cell cycle control, checkpoint mechanisms, and genotoxic stress.Environmental health perspectives · 1999Review
- Association of the mammalian helicase MAH with the pre-mRNA splicing complex.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons.The Journal of cell biology · 1996Article
- Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Quantification of DNA-protein interaction by UV crosslinking.Nucleic acids research · 1995Article
- The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells.Molecular and cellular biology · 1995Article
- Inhibition of apoptosis by the retinoblastoma gene product.The EMBO journal · 1995Article
- Reciprocal regulation of the Epstein-Barr virus BamHI-F promoter by EBNA-1 and an E2F transcription factor.Molecular and cellular biology · 1994Article
- The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle.Molecular and cellular biology · 1994Article
- Structure and cell cycle-regulated transcription of the human cyclin A gene.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Regulation of the cellular thymidine kinase gene promoter in simian virus 40-infected cells.Journal of virology · 1993Article
- Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.Molecular and cellular biology · 1993Article
- Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.Journal of virology · 1993Article
- Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications.Annals of hematology · 1992Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
By performing DNase I footprint and band-shift analyses of a 170-base-pair region of the murine thymidine kinase promoter, we identified an inducible DNA binding activity that we named Yi. Yi binding activity was not detected in G0 and G1 extracts, but it was observed as cells crossed the G1/S boundary. Yi proteins bind specifically to a consensus sequence (CCCNCNNNCT) found at three distinct sites in this promoter region. We also observed a murine Sp1 binding activity that was constitutive throughout the cell cycle. We propose that the G1/S-specific Yi binding is important for murine thymidine kinase gene regulation and perhaps also for initiation of DNA synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.