ArticleNitric oxide : biology and chemistry2010
Genome expression profiling and network analysis of nitrite therapy during chronic ischemia: possible mechanisms and interesting molecules.
Article in Nitric oxide : biology and chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.Frontiers in immunology · 2020Article
- Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.Microcirculation (New York, N.Y. : 1994) · 2016Review
- Inorganic nitrite supplementation for healthy arterial aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function.Kidney international · 2012Article
- Nitrite anion stimulates ischemic arteriogenesis involving NO metabolism.American journal of physiology. Heart and circulatory physiology · 2012Article
- Inorganic nitrite therapy: historical perspective and future directions.Free radical biology & medicine · 2011Review
- Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases.Cardiovascular research · 2011Review
- Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling.Cardiovascular research · 2011Review
- Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.Annals of the New York Academy of Sciences · 2010Review
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Authors and funding
4 authors.
Funding
Abstract
Sodium nitrite is widely recognized to be a highly effective NO donor for the treatment of several ischemic tissue disorders. However, mechanisms by which nitrite confers cytoprotection during ischemic disorders remain largely unknown. In this study, we used genome expression profiling approaches to evaluate changes in gene expression in the hind-limb ischemia model using vehicle or sodium nitrite therapy. Sodium nitrite significantly restored ischemic tissue perfusion by day 3 post-ligation which returned to normal by day 7. Genesifter analysis of Affymetrix GeneChip data revealed a significant down-regulation of gene expression profiles at day 3, whereas gene expression profiles were predominantly up-regulated at day 7. Ingenuity network analysis of gene expression profiles at day 3 showed a strong decrease in gene expression from networks associated with immune functions such as acute inflammatory responses, antigen presentation, and humoral immune responses while networks containing increased gene expression profiles were associated with cardiovascular, skeletal, and muscle system development and function. Network analysis of day 7 gene array data revealed predominant up-regulation of genes associated with cell survival, tissue morphology, connective tissue function, skeletal and muscular system development, and lymphoid tissue structure and development. These data suggest that sodium nitrite elicits potent anti-inflammatory and pro-angiogenic gene responses at early time points which is later followed by up-regulation of genes associated with tissue repair and homeostasis.
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