ArticleNeuroscience2010
Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- Serotonergic Suppression of Sustained Synaptic Responses in Rat Oculomotor Neural Integrator Networks.eNeuro · 2025Article
- Nerve-Glial antigen 2: unmasking the enigmatic cellular identity in the central nervous system.Frontiers in immunology · 2024Review
- The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions.Frontiers in neuroscience · 2024Review
- Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission.British journal of pharmacology · 2020Article
- Serotonergic control of GABAergic inhibition in the lateral amygdala.Journal of neurophysiology · 2020Article
- The 5-HTPsychopharmacology · 2018Review
- Serotonin gating of cortical and thalamic glutamate inputs onto principal neurons of the basolateral amygdala.Neuropharmacology · 2017Article
- Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex.Molecular brain · 2017Article
- Attenuation of the anxiogenic effects of cocaine by 5-HTPsychopharmacology · 2017Article
- The Cyclic Vomiting Syndrome Threshold: A Framework for Understanding Pathogenesis and Predicting Successful Treatments.Clinical and translational gastroenterology · 2016Article
- Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism.ACS chemical neuroscience · 2015Review
- Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions.Experimental brain research · 2013Review
- Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.Frontiers in neuroscience · 2013Review
- Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats.Behavioral and brain functions : BBF · 2013Article
- Intrinsic connections in the anterior part of the bed nucleus of the stria terminalis.Journal of neurophysiology · 2013Article
- Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review.Current neuropharmacology · 2013Article
- Central CRF neurons are not created equal: phenotypic differences in CRF-containing neurons of the rat paraventricular hypothalamus and the bed nucleus of the stria terminalis.Frontiers in neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activation of neurons in the bed nucleus of the stria terminalis (BNST) plays a critical role in stress and anxiety-related behaviors. Previously, we have shown that serotonin (5-HT) can directly modulate BNST neuronal excitability by an action at postsynaptic receptors. In this study we built upon that work to examine the effects of 5-HT on excitatory neurotransmission in an in vitro rat BNST slice preparation. Bath application of 5-HT reversibly reduced the amplitude of evoked excitatory postsynaptic currents (eEPSCs). These effects were mimicked by the 5-HT(1B/D) receptor agonist, sumatriptan, and by the 5-HT(1B) receptor selective agonist, CP93129. Conversely, the effects of 5-HT and sumatriptan could be blocked by the 5-HT(1B) receptor-selective antagonist, GR55562. In contrast, the 5-HT(1A) receptor agonist 8-OH DPAT or antagonist WAY 100635 could not mimic or block the effect of 5-HT on eEPSCs. Together, these data suggest that the 5-HT-induced attenuation of eEPSCs was mediated by 5-HT(1B) receptor activation. Moreover, sumatriptan had no effect on the amplitude of the postsynaptic current elicited by pressure applied AMPA, suggesting a possible presynaptic locus for the 5-HT(1B) receptor. Furthermore, 5-HT, sumatriptan and CP93129 all increased the paired pulse ratio of eEPSCs while they concomitantly decreased the amplitude of eEPSCs, suggesting that these agonists act to reduce glutamate release probability at presynaptic locus. Consistent with this observation, sumatriptan decreased the frequency of miniature EPSCs, but had no effect on their amplitude. Taken together, these results suggest that 5-HT suppresses glutamatergic neurotransmission in the BNST by activating presynaptic 5-HT(1B) receptors to decrease glutamate release from presynaptic terminals. This study illustrates a new pathway by which the activity of BNST neurons can be indirectly modulated by 5-HT, and suggests a potential new target for the development of novel treatments for depression and anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.