ArticleNeuroscience letters2010
Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes.
Article in Neuroscience letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Regulation of extracellular progranulin in medial prefrontal cortex.Neurobiology of disease · 2023Article
- Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases.Diagnostics (Basel, Switzerland) · 2022Review
- Serum level measurement of progranulin in relapsing-remitting multiple sclerosis and neuromyelitis optica patients.American journal of clinical and experimental immunology · 2019Article
- Synaptic Elimination in Neurological Disorders.Current neuropharmacology · 2019Review
- CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.EMBO molecular medicine · 2018Article
- Progranulin in the hematopoietic compartment protects mice from atherosclerosis.Atherosclerosis · 2018Article
- Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome-Sign of Inflammation.Frontiers in neurology · 2018Article
- Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Review
- Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.PloS one · 2014Article
- Article
- Progranulin: at the interface of neurodegenerative and metabolic diseases.Trends in endocrinology and metabolism: TEM · 2013Review
- Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.The Journal of biological chemistry · 2012Review
- Circulating progranulin as a biomarker for neurodegenerative diseases.American journal of neurodegenerative disease · 2012Article
- Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia.PloS one · 2012Article
- Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males.Genes and immunity · 2010Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Progranulin has recently attracted attention due to the discovery of mutations in its encoding gene (GRN) in several cases of frontotemporal lobar degeneration, but also for a possible role in inflammatory processes. In adult central nervous system, GRN mRNA is expressed in forebrain, olfactory bulbs and spinal cord. Progranulin cerebrospinal fluid (CSF) levels were evaluated in 55 patients with multiple sclerosis (MS) as well as in 35 subjects with non-inflammatory neurological diseases (NIND), 7 individuals with other inflammatory neurological disease (OIND) and 8 controls (CON), matched for ethnic background, gender and age. No statistically significant differences were found in patients compared with either NIND, OIND or CON (P>0.05), even stratifying according to disease subtype or gender. A positive correlation between progranulin CSF levels and age was observed in patients (rho=0.29, P=0.03). According to these data, progranulin does not likely play a major role in the pathogenesis of MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.