ArticleBMC cancer2009
Long term survival following the detection of circulating tumour cells in head and neck squamous cell carcinoma.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Application of CellSearch technique in detection of peripheral blood circulating tumour cell count in patients with head and neck cancer and its association with prognosis.Oncology letters · 2025Article
- The Emerging Role of Natural Products in Cancer Treatment.Archives of toxicology · 2024Review
- Review
- Efficient capture of circulating tumor cells with low molecular weight folate receptor-specific ligands.Scientific reports · 2022Article
- Circulating Tumor Cell Detection during Neoadjuvant Chemotherapy to Predict Early Response in Locally Advanced Oropharyngeal Cancers: A Prospective Pilot Study.Journal of personalized medicine · 2022Article
- Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck.Laryngoscope investigative otolaryngology · 2020Article
- Detection of circulating tumor cells in patients with laryngeal cancer using ScreenCell: Comparative pre- and post-operative analysis and association with prognosis.Oncology letters · 2020Article
- Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives.Cancers · 2019Review
- Evaluation of therapeutic efficacy with CytoSorterCancer management and research · 2019Article
- Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas.Scientific reports · 2016Article
- Cell-Free RNA Content in Peripheral Blood as Potential Biomarkers for Detecting Circulating Tumor Cells in Non-Small Cell Lung Carcinoma.International journal of molecular sciences · 2016Article
- Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study.Oncotarget · 2016Article
- Circulating tumor cells in head and neck cancer: A review.World journal of otorhinolaryngology - head and neck surgery · 2016Review
- Diagnostic technologies for circulating tumour cells and exosomes.Bioscience reports · 2015Review
- An optimised direct lysis method for gene expression studies on low cell numbers.Scientific reports · 2015Article
- Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.Epigenetics · 2014Article
- Detection of circulating tumor cell subpopulations in patients with head and neck squamous cell carcinoma (HNSCC).PloS one · 2014Article
- Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis.Cancer cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTechniques for detecting circulating tumor cells in the peripheral blood of patients with head and neck cancers may identify individuals likely to benefit from early systemic treatment.
methodsReconstruction experiments were used to optimise immunomagnetic enrichment and RT-PCR detection of circulating tumor cells using four markers (ELF3, CK19, EGFR and EphB4). This method was then tested in a pilot study using samples from 16 patients with advanced head and neck carcinomas.
resultsSeven patients were positive for circulating tumour cells both prior to and after surgery, 4 patients were positive prior to but not after surgery, 3 patients were positive after but not prior to surgery and 2 patients were negative. Two patients tested positive for circulating cells but there was no other evidence of tumor spread. Given this patient cohort had mostly advanced disease, as expected the detection of circulating tumour cells was not associated with significant differences in overall or disease free survival.
conclusionFor the first time, we show that almost all patients with advanced head and neck cancers have circulating cells at the time of surgery. The clinical application of techniques for detection of spreading disease, such as the immunomagnetic enrichment RT-PCR analysis used in this study, should be explored further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.