Evidence map›Paper›PMID 19961618›Full record

SynthesisBMC public health2009

The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review.

Jürgen Rehm, Andriy V Samokhvalov, Manuela G Neuman, Robin Room, Charles Parry, Knut Lönnroth, Jayadeep Patra, Vladimir Poznyak, Svetlana Popova

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC public health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03302299 (URBAN ARCH), which is not on this map. Cited by 206 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03302299 phase4completednot on this mapstarted 2017, after this paper: background citation

URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy for HIV-infected Alcohol Users in Uganda: an Evaluation of Safety Tolerability and Adherence

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2021Enrolled302ConditionsTuberculosis, HIV/AIDS, Alcohol AbuseArmsIsoniazid 300 Mg ORAL TABLET, Pyridoxine 25 Mg Oral Tablet
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
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  5. The impact of alcohol use on tuberculosis treatment outcomes: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020
    Pooled it
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  12. Disability associated with alcohol abuse and dependence.Alcoholism, clinical and experimental research · 2010
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  14. Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jürgen RehmPublic Health and Regulatory Policies, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. jtrehm@aol.com
Andriy V Samokhvalov
Manuela G Neuman
Robin Room
Charles Parry
Knut Lönnroth
Jayadeep Patra
Vladimir Poznyak
Svetlana Popova

Funding

COOPERATIVE AGREEGMENT TO THE MEDI RESEARC COUNCIL (MRC) OF SOUTH AFRICA FOR TBU51PS000729 · PS · MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA · PI MBEWU, ANTHONY DAVID · 2007 to 2011
$10.0M
NCHHSTP CDC HHS 1U51PS000729-01
6 · The paper itself

Abstract

backgroundIn 2004, tuberculosis (TB) was responsible for 2.5% of global mortality (among men 3.1%; among women 1.8%) and 2.2% of global burden of disease (men 2.7%; women 1.7%). The present work portrays accumulated evidence on the association between alcohol consumption and TB with the aim to clarify the nature of the relationship.

methodsA systematic review of existing scientific data on the association between alcohol consumption and TB, and on studies relevant for clarification of causality was undertaken.

resultsThere is a strong association between heavy alcohol use/alcohol use disorders (AUD) and TB. A meta-analysis on the risk of TB for these factors yielded a pooled relative risk of 2.94 (95% CI: 1.89-4.59). Numerous studies show pathogenic impact of alcohol on the immune system causing susceptibility to TB among heavy drinkers. In addition, there are potential social pathways linking AUD and TB. Heavy alcohol use strongly influences both the incidence and the outcome of the disease and was found to be linked to altered pharmacokinetics of medicines used in treatment of TB, social marginalization and drift, higher rate of re-infection, higher rate of treatment defaults and development of drug-resistant forms of TB. Based on the available data, about 10% of the TB cases globally were estimated to be attributable to alcohol.

conclusionThe epidemiological and other evidence presented indicates that heavy alcohol use/AUD constitute a risk factor for incidence and re-infection of TB. Consequences for prevention and clinical interventions are discussed.

Indexed as

Alcohol DrinkingAlcohol-Related DisordersFemaleHumansMaleMycobacterium tuberculosisPrevalenceRisk FactorsRussiaTuberculosisUkraine

Identifiers

PMID19961618
PMCPMC2796667

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.