ArticleFibrogenesis & tissue repair2009
Role of host genetics in fibrosis.
Article in Fibrogenesis & tissue repair, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells.Journal of clinical and experimental hematopathology : JCEH · 2024Review
- Interleukin 4/13 signaling in cardiac regeneration and repair.American journal of physiology. Heart and circulatory physiology · 2022Review
- Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice.Inflammation · 2020Article
- Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma.Scientific reports · 2019Article
- Low-grade infections as a possible cause of arthrofibrosis after total knee arthroplasty.Patient safety in surgery · 2019Article
- Comparison ofIranian journal of pathology · 2017Article
- The Pressure of Aging.The Medical clinics of North America · 2017Review
- Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients.World journal of gastroenterology · 2016Article
- Autoimmune Myelofibrosis in Systemic Lupus Erythematosus Report of Two Cases and Review of the Literature.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Article
- Advances in Skin Substitutes-Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing.Journal of functional biomaterials · 2015Review
- Donor caveolin 1 (CAV1) genetic polymorphism influences graft function after renal transplantation.Fibrogenesis & tissue repair · 2015Article
- Pathogenesis and treatment of hepatic fibrosis: is cirrhosis reversible?Clinical medicine (London, England) · 2011Review
- Evolving challenges in hepatic fibrosis.Nature reviews. Gastroenterology & hepatology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis can occur in tissues in response to a variety of stimuli. Following tissue injury, cells undergo transformation or activation from a quiescent to an activated state resulting in tissue remodelling. The fibrogenic process creates a tissue environment that allows inflammatory and matrix-producing cells to invade and proliferate. While this process is important for normal wound healing, chronicity can lead to impaired tissue structure and function.This review examines the major factors involved in transforming or activating tissues towards fibrosis. The role of genetic variation within individuals affected by fibrosis has not been well described and it is in this context that we have examined the mediators of remodelling, including transforming growth factor-beta, T helper 2 cytokines and matrix metalloproteinases.Finally we examine the role of Toll-like receptors in fibrosis. The inflammatory phenotype that precedes fibrosis has been associated with Toll-like receptor activation. This is particularly important when considering gastrointestinal and hepatic disease, where inappropriate Toll-like receptor signalling, in response to the local microbe-rich environment, is thought to play an important role.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.