Evidence map›Paper›PMID 1996120›Full record

ArticleMolecular and cellular biology1991

The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.

B C Varnum, Q F Ma, T H Chi, B Fletcher, H R Herschman

Open access · greenAbstract readComparative Study
In one paragraph

Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 158 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Beyond transcription: RNA-binding proteins steering angiogenesis.American journal of physiology. Heart and circulatory physiology · 2026
    Review
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  6. Review
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  11. Article
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  16. Article
  17. RNA binding proteins as regulators of immune cell biology.Clinical and experimental immunology · 2016
    Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

B C VarnumDepartment of Biological Chemistry, University of California Los Angeles Center for the Health Sciences 90024.
Q F Ma
T H Chi
B Fletcher
H R Herschman
MRC Laboratory of Molecular Biology · GBUniversity of California, Los Angeles · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETIC MECHANISMS AT UCT32GM007104 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOBER, JAMES W · 1985 to 2011
$3.6M
INITIATION OF CELLULAR PROLIFERATIONR01GM024797 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HERSCHMAN, HARVEY R. · 1985 to 1998
–
NIDCR NIH HHS DE FC03 87ER60615NIGMS NIH HHS 2T32 GM07104NIGMS NIH HHS GM24797
6 · The paper itself

Abstract

The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors. The predicted TIS11 protein contains a 6-amino-acid repeat, YKTELC. We cloned two additional cDNAs, TIS11b and TIS11d, that contain the YKTELC sequence. TIS11, TIS11b, and TIS11d proteins share a 67-amino-acid region of sequence similarity that includes the YKTELC repeat and two cysteine-histidine containing repeats. TIS11 gene family members are not coordinately expressed: (i) unlike TIS11, the TIS11b and TIS11d mRNAs are detectable in quiescent Swiss 3T3 cells and are not dramatically induced by 12-O-tetradecanoylphorbol-13-acetate; (ii) cycloheximide superinduction does not occur for TIS11b and TIS11d; and (iii) unlike TIS11, TIS11b expression is extinguished in PC12 pheochromocytoma cells.

Indexed as

DNA-Binding ProteinsImmediate-Early ProteinsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernCloning, MolecularDNAEpidermal Growth FactorFibroblast Growth FactorsGene ExpressionMiceMice, Inbred BALB CMolecular Sequence DataMultigene FamilyNerve Growth FactorsDNADNA-Binding ProteinsEpidermal Growth FactorFibroblast Growth FactorsImmediate-Early ProteinsNerve Growth FactorsOligonucleotidesProteinsTetradecanoylphorbol AcetateTristetraprolinZfp36 protein, mouse

Identifiers

PMID1996120
PMCPMC369492
OpenAlexW2161365750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.