ArticleWorld journal of gastroenterology2009
Shift work aggravates metabolic syndrome development among early-middle-aged males with elevated ALT.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Shift work and vascular events: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2012Pooled it
- Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.Hepatoma research · 2024Article
- Emergency Medical Services Clinicians Have a High Prevalence of Metabolic Syndrome.Prehospital emergency care · 2023Review
- Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood.Frontiers in public health · 2022Article
- Sleep, Sleep Disorders, and Sexual Dysfunction.The world journal of men's health · 2019Review
- The Case for Addressing Operator Fatigue.Review of human factors and ergonomics · 2015Article
- The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms.Diabetology & metabolic syndrome · 2015Article
- Protecting the melatonin rhythm through circadian healthy light exposure.International journal of molecular sciences · 2014Review
- Supplementary use of HbA1c as hyperglycemic criterion to detect metabolic syndrome.Diabetology & metabolic syndrome · 2014Article
- Circadian Rhythm Sleep Disorders.Journal of clinical outcomes management : JCOM · 2013Article
- Time-of-day and nutrient composition of eating occasions: prospective association with the metabolic syndrome in the 1946 British birth cohort.International journal of obesity (2005) · 2013Article
- The effects of shift work on physical and mental health.Journal of neural transmission (Vienna, Austria : 1996) · 2012Review
- Elevated alanine aminotransferase activity is not associated with dyslipidemias, but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease.Asian Pacific journal of tropical biomedicine · 2012Article
- Effect of rotating shift work on childbearing and birth weight: a study of women working in a semiconductor manufacturing factory.World journal of pediatrics : WJP · 2011Article
- Article
- Shift work and chronic disease: the epidemiological evidence.Occupational medicine (Oxford, England) · 2011Review
- Excessive 5-year weight gain predicts metabolic syndrome development in healthy middle-aged adults.World journal of diabetes · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine whether shift work accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT).
methodsA retrospective, observational follow-up study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfilling MetS criteria at screening were enrolled. Age, MetS-components, liver enzymes, serological markers for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and workplace factors were analyzed.
resultsThe prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) workers with long-term exposures to day-night rotating shift work (RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the workers with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Workers with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW workers had a significant increase in MetS-components at follow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW workers posed a significant risk for MetS development (odds ratio, 2.7; 95% confidence interval, 1.4-5.3, vs workers without baseline e-ALT nor pRSW).
conclusionWe suggest that all early middle-aged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.