ArticleJournal of molecular neuroscience : MN2010
Triplet puzzle: homologies of receptor heteromers.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- A structural overview of G-protein-coupled receptors in neurological disorders.Acta pharmacologica Sinica · 2026Review
- Evolutionary Couplings and Molecular Dynamic Simulations Highlight Details of GPCRs Heterodimers' Interfaces.Molecules (Basel, Switzerland) · 2023Article
- The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: potential relevance for brain and behavior.Frontiers in molecular neuroscience · 2022Review
- Structural Characterization of Receptor-Receptor Interactions in the Allosteric Modulation of G Protein-Coupled Receptor (GPCR) Dimers.International journal of molecular sciences · 2021Review
- The Role of Central Serotonin Neurons and 5-HT Heteroreceptor Complexes in the Pathophysiology of Depression: A Historical Perspective and Future Prospects.International journal of molecular sciences · 2021Review
- Allosteric Interactions between Adenosine AInternational journal of molecular sciences · 2021Review
- Adenosine ACells · 2020Review
- Differential allosteric modulation within dopamine DScientific reports · 2019Article
- Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS.Frontiers in molecular neuroscience · 2019Article
- Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?Frontiers in endocrinology · 2019Review
- Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment.Molecules (Basel, Switzerland) · 2018Review
- Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors.Frontiers in synaptic neuroscience · 2018Review
- Article
- Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease.Frontiers in cellular neuroscience · 2017Review
- IL1R2, CCR2, and CXCR4 May Form Heteroreceptor Complexes with NMDAR and D2R: Relevance for Schizophrenia.Frontiers in psychiatry · 2017Article
- Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia.Therapeutic advances in psychopharmacology · 2016Review
- Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes.Neural plasticity · 2016Review
- The triplet puzzle theory indicates extensive formation of heteromers between opioid and chemokine receptor subtypes.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on a mathematical approach, we deduce a set of triplet homologies that may be responsible for receptor-receptor interactions. We show how such triplets of amino acid residues and their 'teams' may be utilized to construct a kind of code that determines (and/or predicts) which receptors should or should not form heterodimers. Based on the obtained results, we propose a 'guide-and-clasp' manner for receptor-receptor interactions where 'adhesive guides' might be the triplet homologies. We also demonstrate their relevance to protein-protein interactions and mention possible implications for novel pharmacological targets and strategies for treatment of diseases, e.g. neuroinflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.