ReviewCurrent topics in microbiology and immunology2010
Co-receptors and recognition of self at the immunological synapse.
Review in Current topics in microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Structure, function, and immunomodulation of the CD8 co-receptor.Frontiers in immunology · 2024Review
- Article
- Genetic architecture of innate and adaptive immune cells in pigs.Frontiers in immunology · 2023Article
- Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity.Nature communications · 2022Article
- Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck.Frontiers in immunology · 2021Article
- Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.Nature communications · 2018Article
- The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Nature immunology · 2014Review
- Self-gratification yields not-so-naive T cells.Nature immunology · 2014Article
- Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.The Journal of experimental medicine · 2013Article
- Orchestration of CD4 T cell epitope preferences after multipeptide immunization.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.European journal of microbiology & immunology · 2012Article
- Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.PloS one · 2012Article
- CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.EMBO reports · 2011Article
- Initiation of TCR phosphorylation and signal transduction.Frontiers in immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The co-receptors CD4 and CD8 are important in the activation of T cells primarily because of their ability to interact with the proteins of the MHC enhancing recognition of the MHC-peptide complex by the T cell receptor (TCR). An antigen-presenting cell presents a small number of antigenic peptides on its MHC molecules, in the presence of a much larger number of endogenous, mostly nonstimulatory, peptides. Recent work has demonstrated that these endogenous MHC-peptide complexes have an important role in modulating the sensitivity of the TCR. But the role of the endogenous nonstimulatory MHC-peptide complexes differs in MHC class I and class II-restricted T cells. This chapter discusses the data on the role of CD4 or CD8 co-receptors in T cell activation at the immunological synapse, and the role of non stimulatory MHC-peptide complexes in aiding antigen recognition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.