Evidence map›Paper›PMID 19960254›Full record

ArticleDigestive diseases and sciences2010

Prevalence of vitamin D deficiency in chronic liver disease.

J Arteh, S Narra, S Nair

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01575717 (The Effect of Vitamin D Repletion in Patients With Hepatocellular Carcinoma on the Orthotopic Liver Transplant List), which is not on this map. Cited by 156 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 8 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01575717 naunknown statusnot on this mapstarted 2012, after this paper: background citation

The Effect of Vitamin D Repletion in Patients With Hepatocellular Carcinoma on the Orthotopic Liver Transplant List

TypeinterventionalSponsorAndrea BranchRan2012 to 2013Enrolled50ConditionsVitamin D Deficiency, Hepatocellular CarcinomaArmsVitamin D3 4000 IU, Vitamin D3 2000 IU
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 8 syntheses or guidelines pooled it, 391 citations in OpenAlex.

  1. Guideline
  2. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Pooled it
  5. Pooled it
  6. An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012
    Guideline
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. The Liver-Bone Axis in Steatotic Liver Disease.Calcified tissue international · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J ArtehDepartment of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
S Narra
S Nair
University of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledVitamin D deficiency has been associated with cholestatic liver disease such as primary biliary cirrhosis. Some studies have suggested that cirrhosis can predispose patients to development of osteoporosis because of altered calcium and vitamin D homeostasis. The aim of this study was to determine the prevalence of vitamin D deficiency in patients with chronic liver disease.

methodsOne hundred and eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-related cirrhosis) attending the University of Tennessee Hepatology Clinic had their 25-hydroxyvitamin D level measured. Severity of vitamin D deficiency was graded as mild (20-32 ng/ml), moderate (7-19 ng/ml) or severe (<7 ng/ml), normal being >32 ng/ml.

resultsOf patients, 109/118 (92.4%) had some degree of vitamin D deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) had mild, 48.8% (21/43) had moderate, and 30.2% (13/43) had severe vitamin D deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) had mild, 52.6% (30/57) had moderate, and 14% (8/57) had severe vitamin D deficiency. In the nonhepatitis C-related cirrhosis group, 38.9% (7/18) had mild, 27.8% (5/18) had moderate, and 27.8% (5/18) had severe vitamin D deficiency. Severe vitamin D deficiency (<7 ng/ml) was more common among patients with cirrhosis compared with noncirrhotics (29.5% versus 14.1%, P value=0.05). Female gender, African American race, and cirrhosis were independent predictors of severe vitamin D deficiency in chronic liver disease.

conclusionVitamin D deficiency is universal (92%) among patients with chronic liver disease, and at least one-third of them suffer from severe vitamin D deficiency. African American females are at highest risk of vitamin D deficiency.

Indexed as

AdultAgedBiomarkersBlack or African AmericanChi-Square DistributionFemaleHepatitis C, ChronicHumansLiver CirrhosisLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceRisk AssessmentRisk Factors25-hydroxyvitamin DBiomarkersVitamin D

Identifiers

PMID19960254
OpenAlexW2079105341

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.