ArticleObstetrics and gynecology international2009
The effect of Acid-reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy.
Article in Obstetrics and gynecology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 90 citations in OpenAlex.
- Article
- Treatment options for hyperemesis gravidarum.Archives of women's mental health · 2017Review
- Nausea and vomiting of pregnancy - What's new?Autonomic neuroscience : basic & clinical · 2017Review
- Treatment of nausea in pregnancy: a cross-sectional multinational web-based study of pregnant women and new mothers.BMC pregnancy and childbirth · 2015Article
- Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial.Obstetrics and gynecology international · 2013Article
- Nausea and vomiting of pregnancy.Gastroenterology clinics of North America · 2011Review
- Optimal management of nausea and vomiting of pregnancy.International journal of women's health · 2010Article
- Managing hyperemesis gravidarum: a multimodal challenge.BMC medicine · 2010Review
- Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy.Canadian family physician Medecin de famille canadien · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid-reducing drugs resulted in significant decreases in PUQE (9.6 +/- 3.0 to 6.5 +/- 2.5, P < .0001) and well-being scores from the initial (4.0 +/- 2.0) to the follow-up interview (6.8 +/- 1.6, P < .0001). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R(2) = 0.72, P < .001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.