ArticleActa pharmacologica Sinica2009
Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families.
Article in Acta pharmacologica Sinica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03279432 (Vitamin D Receptor and Megalin Gene Polymorphisms and Their Association With Obesity, Central Obesity and the Metabolic Syndrome), which is not on this map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin D Receptor and Megalin Gene Polymorphisms and Their Association With Obesity, Central Obesity and the Metabolic Syndrome
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Multiple Origins and Genomic Basis of Complex Traits in Sighthounds.Molecular biology and evolution · 2023Article
- Effect of vitamin DJournal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023Article
- Stress and human health in diabetes: A report from the 19Journal of clinical and translational science · 2023Article
- Article
- The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review.Journal of diabetes and metabolic disorders · 2020Review
- Association between LGR4 polymorphisms and peak bone mineral density and body composition.Journal of bone and mineral metabolism · 2020Article
- Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women.Nutrients · 2020Article
- Vitamin D Metabolism-Related Gene Haplotypes and Their Association with Metabolic Disturbances Among African-American Urban Adults.Scientific reports · 2018Article
- Transcription Factor Co-expression Networks of Adipose RNA-Seq Data Reveal Regulatory Mechanisms of Obesity.Current genomics · 2018Article
- Association of Sun Exposure, Skin Colour and Body Mass Index with Vitamin D Status in Individuals Who Are Morbidly Obese.Nutrients · 2017Article
- Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families.Journal of bone and mineral metabolism · 2017Article
- Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population.Journal of genetics · 2015Article
- Polymorphisms in the vitamin D receptor and risk of gout in Chinese Han male population.Rheumatology international · 2015Article
- Mechanisms of obesity-induced gastrointestinal neoplasia.Gastroenterology · 2014Review
- Control of body weight versus tumorigenesis by concerted action of leptin and estrogen.Reviews in endocrine & metabolic disorders · 2013Review
- Vitamin D receptor and megalin gene polymorphisms are associated with central adiposity status and changes among US adults.Journal of nutritional science · 2013Article
- Contribution of myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring.Acta pharmacologica Sinica · 2012Article
- Bone mineral density-associated polymorphisms are associated with obesity-related traits in Korean adults in a sex-dependent manner.PloS one · 2012Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe goal of this study was to determine whether polymorphisms in the vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) genes are associated with variations of peak bone mineral density (BMD) and obesity phenotypes in young Chinese men.
methodsA total of 1215 subjects from 400 Chinese nuclear families were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific multiple PCR (ASM-PCR) analysis at the ApaI, FokI, and CDX2 sites in the VDR gene and the PvuII and XbaI sites in the ESR1 gene. BMD at the lumbar spine and hip, total fat mass, and total lean mass were measured using dual energy X-ray absorptiometry. The associations between VDR and ESR1 gene polymorphisms with peak BMD, body mass index (BMI), total fat mass, total lean mass, and percentage fat mass (PFM) were determined using quantitative transmission disequilibrium tests (QTDTs).
resultsUsing QTDTs, no significant within-family associations were obtained between genotypes or haplotypes of the VDR and ESR1 genes and peak BMD. For the obesity phenotypes, the within-family associations were significant between CDX2 genotypes and BMI (P=0.046), fat mass (P=0.004), and PFM (P=0.020). Further, PvuII was significantly associated with the variation of fat mass and PFM (P=0.002 and P=0.039, respectively). A subsequent 1000 permutations were in agreement with these within-family association results.
conclusionOur findings showed that VDR and ESR1 polymorphisms were associated with total fat mass in young Chinese men, but we failed to find a significant association between VDR and ESR1 genotypes and peak BMD. These findings suggested that the VDR and ESR1 genes are quantitative trait loci (QTL) underlying fat mass variation in young Chinese men.
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