ArticleThe Journal of clinical investigation2009
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.
Article in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- A meta-analysis of gene expression signatures of blood pressure and hypertension.PLoS genetics · 2015Pooled it
- Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Enrichment of mutant calmodulin protein in a murine model of a human calmodulinopathy.JCI insight · 2025Article
- The Sympathetic Nervous System in Hypertension: Roadmap Update of a Long Journey.American journal of hypertension · 2021Article
- Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.PloS one · 2021Article
- Uncharacterized RNAs in Plasma of Alzheimer's Patients Are Associated with Cognitive Impairment and Show a Potential Diagnostic Power.International journal of molecular sciences · 2020Article
- Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function.Biophysical journal · 2017Article
- Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein.The Journal of biological chemistry · 2015Article
- Role of the sympathetic nervous system in hypertension and hypertension-related cardiovascular disease.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2014Review
- Structural modulation of phosducin by phosphorylation and 14-3-3 protein binding.Biophysical journal · 2012Article
- Phosphorylation of phosducin accelerates rod recovery from transducin translocation.Investigative ophthalmology & visual science · 2012Article
- T lymphocytes and vascular inflammation contribute to stress-dependent hypertension.Biological psychiatry · 2012Article
- Disorders of blood pressure regulation-role of catecholamine biosynthesis, release, and metabolism.Current hypertension reports · 2012Review
- A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.PloS one · 2012Article
- Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Neuro-endocrine regulation of blood pressure.Indian journal of endocrinology and metabolism · 2011Article
- Sumoylation of hypoxia-inducible factor-1α ameliorates failure of brain stem cardiovascular regulation in experimental brain death.PloS one · 2011Article
- The physiological roles of phosducin: from retinal function to stress-dependent hypertension.Cellular and molecular life sciences : CMLS · 2011Review
- {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice.The Journal of biological chemistry · 2010Article
- Advances in genome studies: The PAG 2010 conference.Functional & integrative genomics · 2010Article
Corrections and comments
- Commented on by
- Erratum issuedLorkowski, Stefan [added]
Authors and funding
26 authors at 11 institutions in 5 countries.
Funding
Abstract
Hypertension and its complications represent leading causes of morbidity and mortality. Although the cause of hypertension is unknown in most patients, genetic factors are recognized as contributing significantly to an individual's lifetime risk of developing the condition. Here, we investigated the role of the G protein regulator phosducin (Pdc) in hypertension. Mice with a targeted deletion of the gene encoding Pdc (Pdc-/- mice) had increased blood pressure despite normal cardiac function and vascular reactivity, and displayed elevated catecholamine turnover in the peripheral sympathetic system. Isolated postganglionic sympathetic neurons from Pdc-/- mice showed prolonged action potential firing after stimulation with acetylcholine and increased firing frequencies during membrane depolarization. Furthermore, Pdc-/- mice displayed exaggerated increases in blood pressure in response to post-operative stress. Candidate gene-based association studies in 2 different human populations revealed several SNPs in the PDC gene to be associated with stress-dependent blood pressure phenotypes. Individuals homozygous for the G allele of an intronic PDC SNP (rs12402521) had 12-15 mmHg higher blood pressure than those carrying the A allele. These findings demonstrate that PDC is an important modulator of sympathetic activity and blood pressure and may thus represent a promising target for treatment of stress-dependent hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.