ReviewThe Journal of clinical investigation2009
Resolution of immune activation defines nonpathogenic SIV infection.
Review in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.Virology · 2022Article
- Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.PLoS pathogens · 2021Article
- Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Type I interferons in viral control and immune regulation.Current opinion in virology · 2016Review
- Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses.Advances in immunology · 2016Review
- Regulation of antiviral T cell responses by type I interferons.Nature reviews. Immunology · 2015Review
- Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers.Mucosal immunology · 2014Article
- Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection.Current HIV research · 2014Review
- SIV infection of rhesus macaques differentially impacts mononuclear phagocyte responses to virus-derived TLR agonists.Journal of medical primatology · 2013Article
- Immune activation and collateral damage in AIDS pathogenesis.Frontiers in immunology · 2013Review
- Persistent LCMV infection is controlled by blockade of type I interferon signaling.Science (New York, N.Y.) · 2013Article
- Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Journal of virology · 2013Article
- Simian immunodeficiency virus interactions with macaque dendritic cells.Advances in experimental medicine and biology · 2013Review
- Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.AIDS research and human retroviruses · 2013Article
- Critical dynamics in host-pathogen systems.Current topics in microbiology and immunology · 2013Review
- Plasmacytoid dendritic cells in HIV infection.Advances in experimental medicine and biology · 2013Review
- Systems biology of the vervet monkey.ILAR journal · 2013Review
- Dynamics of innate immunity are key to chronic immune activation in AIDS.Current opinion in HIV and AIDS · 2012Review
- Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.Current opinion in HIV and AIDS · 2011Review
Corrections and comments
- Comment on
- Comment on
Authors and funding
2 authors.
Funding
Abstract
Natural nonhuman primate hosts of SIV do not succumb to AIDS despite significant viral replication, a phenomenon attributed to reduced levels of chronic and deleterious "immune activation." Two studies in this issue of the JCI, by Bosinger et al. and Jacquelin et al., now show that SIV induces vigorous immune activation and upregulation of IFN-stimulated genes in both natural and susceptible hosts, but strikingly, the responses resolve only in the former (see the related articles, beginning on pages 3556 and 3544, respectively). Thus, natural hosts for SIV actively engage mechanisms to abort sustained immune activation and its associated harmful effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.