ArticleDiabetes2010
Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Effect of Gender on Serum Leptin in Type 2 Diabetes Mellitus: A System Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review.Metabolism: clinical and experimental · 2015Pooled it
- Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir.Molecules (Basel, Switzerland) · 2017Trial
- Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.Frontiers in endocrinology · 2026Article
- History of Breastfeeding in Relation to Circulating Inflammatory and Metabolic Biomarkers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- 24-h urinary sodium and potassium excretions, plasma metabolomic profiles, and cardiometabolic biomarkers in the United States adults: a cross-sectional study.The American journal of clinical nutrition · 2024Article
- Adipo-oncology: adipocyte-derived factors govern engraftment, survival, and progression of metastatic cancers.Cell communication and signaling : CCS · 2024Review
- A study to investigate genetic factors associated with weight gain in people with diabetes: analysis of polymorphisms in four relevant genes.Adipocyte · 2023Article
- The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity.Nutrients · 2023Review
- You are What You Drink? How Associations Between Profiles of Beverage Consumption and Type 2 Diabetes Risk are Mediated by Biomarker Networks.The American journal of clinical nutrition · 2023Article
- Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans.The Journal of clinical endocrinology and metabolism · 2023Article
- Triglycerides and leptin soluble receptor: Which one is the target to protect β-cells in patients with type 2 diabetes?Frontiers in endocrinology · 2023Article
- Circulating Ism1 Reduces the Risk of Type 2 Diabetes but not Diabetes-Associated NAFLD.Frontiers in endocrinology · 2022Article
- Adipokines as potential biomarkers for type 2 diabetes mellitus in cats.Frontiers in immunology · 2022Review
- Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program.Obesity (Silver Spring, Md.) · 2022Article
- Association of insulin resistance and leptin receptor gene polymorphism in type 2 diabetes mellitus.Journal of the Chinese Medical Association : JCMA · 2021Article
- Review
- Metabolomics and Proteomics in Type 2 Diabetes.Circulation research · 2020Review
- Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring.International journal of environmental research and public health · 2020Article
- Longitudinal changes in adipokines and free leptin index during and after pregnancy in women with obesity.International journal of obesity (2005) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveWe prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk. RESEARCH DESIGN AND
methodsOf 32,826 Nurses' Health Study participants who provided blood samples during 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.
resultsAfter multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.
conclusionsThese data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.