ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Relationship between cigarette smoking and human papilloma virus types 16 and 18 DNA load.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort.International journal of cancer · 2026Article
- Human Papillomavirus (HPV) and Infertility: A Cross-Sectional Study Exploring Its Prevalence and Effects in Iranian Couples.Health science reports · 2025Article
- Association between human papillomavirus and behaviour, clinicopathology, and cervical cancer outcome in Zimbabwean women: a cross-sectional study.Reproductive health · 2025Article
- Prevalence and Associated Factors for HPV in People Living with HIV: Are INSTIs Protective Against HPV-16? The GAIA Study.Viruses · 2025Article
- Evaluating intersectional variation of HPV-associated cancers in rural America.BMC public health · 2025Article
- Clinical characteristics and prognostic impact of HPV infection in head and neck cancer patients in china: a nationwide multicenter study.Infectious agents and cancer · 2025Article
- Impact of HPV test results and emotional responses on psychosocial burden among Taiwanese women: a cross-sectional study.BMC women's health · 2025Observational
- Association between serum P16ink4A concentration and CIN and cervical cancer among women attending a cervical cancer clinic in western Uganda: A case control study.Gynecologic oncology reports · 2024Article
- Preoperative Circulating Tumor HPV DNA and Oropharyngeal Squamous Cell Disease.JAMA otolaryngology-- head & neck surgery · 2024Article
- Diagnostic accuracy of HPV16 early antigen serology for HPV-driven oropharyngeal cancer is independent of age and sex.International journal of cancer · 2024Article
- Frequency ofIranian journal of pathology · 2024Article
- Review
- Article
- Preventing Persistence of HPV Infection with Natural Molecules.Pathogens (Basel, Switzerland) · 2023Review
- HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK.Pathogens (Basel, Switzerland) · 2023Review
- Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women.Pathogens (Basel, Switzerland) · 2023Article
- The Association between Smoking and Anal Human Papillomavirus in the HPV Infection in Men Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Trends in Incidence and Mortality of Gynecological and Breast Cancers in Poland (1980-2018).Clinical epidemiology · 2022Article
- Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.International journal of molecular and cellular medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundAlthough cigarette smoking has been associated with increased human papilloma virus (HPV) detection, its impact on HPV DNA load is unknown.
methodsThe study subjects were women who were positive for HPV16 and/or HPV18 at enrollment into the Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study. Assessments of exposure to smoke and sexual behavior were based on self-report. Viral genome copies per nanogram of cellular DNA were measured by multiplex real-time PCR. Linear or logistic regression models were used to assess the relationship between cigarette smoking and baseline viral load.
resultsOf the 1,050 women (752 with HPV16, 258 with HPV18, and 40 with both HPV16 and HPV18), 452 (43.0%) were current smokers and 101 (9.6%) were former smokers at enrollment. The baseline viral load was statistically significantly greater for current compared with never smokers (P = 0.03 for HPV16; P = 0.02 for HPV18) but not for former smokers. Among current smokers, neither HPV16 nor HPV18 DNA load seemed to vary appreciably by age at smoking initiation, smoking intensity, or smoking duration. The results remained similar when the analysis of smoking-related HPV16 DNA load was restricted to women without detectable cervical abnormality.
conclusionHigher baseline HPV16 and HPV18 DNA load was associated with status as a current but not former smoker. A lack of dose-response relationship between cigarette smoking and viral load may indicate a low threshold for the effect of smoking on HPV DNA load.
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