ReviewCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Clinical trials methods for evaluation of potential reduced exposure products.
Review in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measures for assessing subjective effects of potential reduced-exposure products.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Pooled it
- Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following exclusive and partial switching from combustible cigarettes to mybluInternal and emergency medicine · 2022Trial
- A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Oral tobacco products: preference and effects among smokers.Drug and alcohol dependence · 2011Trial
- Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Article
- Consortium on Methods Evaluating Tobacco: Research Tools to Inform US Food and Drug Administration Regulation of Snus.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Review
- Cigarette Filter Ventilation and its Relationship to Increasing Rates of Lung Adenocarcinoma.Journal of the National Cancer Institute · 2017Review
- Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Expanding clinical laboratory tobacco product evaluation methods to loose-leaf tobacco vaporizers.Drug and alcohol dependence · 2016Article
- Behavioral Economic Laboratory Research in Tobacco Regulatory Science.Tobacco regulatory science · 2016Article
- Reference change values in concentrations of urinary and salivary biomarkers of exposure and mouth level exposure in individuals participating in an ambulatory smoking study.Practical laboratory medicine · 2016Article
- Preliminary Evaluation of a New German Translated Tobacco Quality of Life Impact Tool to Discriminate Between Healthy Current and Former Smokers and to Explore the Effect of Switching Smokers to a Reduced Toxicant Prototype Cigarette.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States.Health and quality of life outcomes · 2015Article
- Providing a Science Base for the Evaluation of Tobacco Products.Tobacco regulatory science · 2015Article
- Article
- Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Article
- Tobacco and nicotine product testing.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Postmarketing surveillance for "modified-risk" tobacco products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Electronic nicotine delivery systems: a research agenda.Tobacco control · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Potential reduced exposure products (PREPs) to tobacco toxicants may have promise in reducing tobacco-related morbidity or mortality or may promote greater harm to individuals or the population. Critical to determining the risks or benefits from these products are valid human clinical trial PREP assessment methods. Such an assessment involves determining the effects of these products on biomarkers of exposure and effect, which serve as proxies for harm, and assessing the potential for consumer uptake and abuse of the product. This article identifies critical methodologic issues associated with PREP assessments, reviews the methods that have been used to assess PREPs, and describes the strengths and limitations of these methods. Additionally, recommendations are provided for clinical trial PREP assessment methods and future research directions in this area based on this review and on the deliberations from a National Cancer Institute sponsored Clinical Trials PREP Methods Workshop.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.