ArticleVirology2010
Xenotropic murine leukemia virus-related virus is susceptible to AZT.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication.mBio · 2024Article
- Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts.Journal of virology · 2014Article
- Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.Viruses · 2014Article
- Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents.Journal of virology · 2013Article
- Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells.PloS one · 2013Article
- Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species.PloS one · 2012Article
- Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection.PloS one · 2012Article
- Article
- Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.Nucleic acids research · 2012Article
- Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome.Diagnostic microbiology and infectious disease · 2011Article
- Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV.Journal of virology · 2011Article
- Severe restriction of xenotropic murine leukemia virus-related virus replication and spread in cultured human peripheral blood mononuclear cells.Journal of virology · 2011Article
- No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.Retrovirology · 2011Article
- Article
- Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari.Journal of virology · 2011Article
- Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein.Human gene therapy · 2010Article
- Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Immunologic research · 2010Article
- Article
- Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors.Retrovirology · 2010Article
- Lack of detection of XMRV in seminal plasma from HIV-1 infected men in The Netherlands.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The xenotropic murine leukemia virus-related virus (XMRV) is a human retrovirus, recently isolated from tissues of prostate cancer patients with impaired RNase L activity. In this study, we evaluated 10 licensed anti-HIV-1 compounds for their activity against XMRV, including protease inhibitors (PI), nucleoside reverse transcriptase (RT) inhibitors (NRTI), non-nucleoside RT inhibitors (NNRTI) and an integrase inhibitor. No PI affected XMRV production; even high concentrations of Ritonavir failed to inhibit the maturation of XMRV Gag polyproteins. Among the NRTI, NNRTI and integrase inhibitors used in this study, only AZT blocked XMRV infection and replication through inhibition of viral reverse transcription. This sensitivity of XMRV to AZT may be explained by the modest homology in the motif D sequences of HIV-1 and XMRV reverse transcriptases. If XMRV becomes established as an etiological agent for prostate cancer or other diseases, AZT may be useful for preventing or treating XMRV infections in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.