ArticleHeart rhythm2009
Arrhythmogenic mechanisms of the Purkinje system during electric shocks: a modeling study.
Article in Heart rhythm, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation.The Journal of physiology · 2026Review
- In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human.Scientific reports · 2024Article
- Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications.Biophysics reviews · 2021Article
- Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium.Frontiers in physiology · 2018Article
- Reducing Error in ECG Forward Simulations With Improved Source Sampling.Frontiers in physiology · 2018Article
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity.Cardiovascular research · 2014Article
- Mechanism of reentry induction by a 9-V battery in rabbit ventricles.American journal of physiology. Heart and circulatory physiology · 2014Article
- Effects of fibrosis morphology on reentrant ventricular tachycardia inducibility and simulation fidelity in patient-derived models.Clinical Medicine Insights. Cardiology · 2014Review
- The role of Purkinje-myocardial coupling during ventricular arrhythmia: a modeling study.PloS one · 2014Article
- Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: mechanistic insights from rabbit ventricular models.Heart rhythm · 2013Article
- The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2013Article
- Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points.Heart rhythm · 2013Article
- Computational approaches to understand cardiac electrophysiology and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2012Review
- Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.The Journal of physiology · 2012Article
- The role of fine-scale anatomical structure in the dynamics of reentry in computational models of the rabbit ventricles.The Journal of physiology · 2012Article
- Estimation of local orientations in fibrous structures with applications to the Purkinje system.IEEE transactions on bio-medical engineering · 2011Article
- A macro finite-element formulation for cardiac electrophysiology simulations using hybrid unstructured grids.IEEE transactions on bio-medical engineering · 2011Article
- Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.Circulation research · 2011Review
- Arrhythmogenesis by single ectopic beats originating in the Purkinje system.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe function of the Purkinje system (PS) is to ensure fast and uniform activation of the heart. Although this vital role during sinus rhythm is well understood, this is not the case when shocks are applied to the heart, especially in the case of failed defibrillation. The PS activates differently from the myocardium, has different electrophysiological properties, and provides alternate propagation pathways; thus, there are many ways in which it can contribute to postshock behavior.
objectiveThe purpose of this study was to elucidate the role of the PS in the initiation and maintenance of postshock arrhythmias.
methodsA computer model of the ventricles including the PS was subjected to different reentry induction protocols.
resultsThe PS facilitated reentry induction at relatively weaker shocks. Disconnecting the PS from the ventricles during the postshock interval revealed that the PS helps stabilize early-stage reentry by providing focal breakthroughs. During later stages, the PS contributed to reentry by leading to higher frequency rotors. The PS also promoted wave front splitting during reentry due to electrotonic coupling, which prolongs action potential durations at PS-myocyte junctions. The presence of a PS results in the anchoring of reentrant activations that propagate through the pathways provided by the PS.
conclusionsThe PS is proarrhythmic in that it provides pathways that prolong activity, and it plays a supplementary role in maintaining the later stages of reentry (>800 ms).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.