ReviewSeminars in radiation oncology2010
Brain tumors across the age spectrum: biology, therapy, and late effects.
Review in Seminars in radiation oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 208 citations in OpenAlex.
- Epidemiology and etiology of brain cancer in Africa: A systematic review.Brain and behavior · 2023Pooled it
- Reirradiation for diffuse intrinsic pontine glioma: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Pooled it
- Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.Journal of neuro-oncology · 2013Pooled it
- A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG).Journal of neuro-oncology · 2020Trial
- Paediatric therapeutic development workshop on medulloblastoma.British journal of cancer · 2026Review
- Multi-omics characterization of radiation-induced cerebellar remodeling and tumorigenic transcriptional programs.Neoplasia (New York, N.Y.) · 2026Article
- Article
- Varied effectiveness of outpatient rehabilitation interventions in reducing long-term complications following childhood brain tumours: a systematic review.Frontiers in rehabilitation sciences · 2026Article
- Pediatric Diffuse High-Grade Gliomas: A Comprehensive Review Of Advanced Methods Of Diagnosis And Treatment.Current cancer drug targets · 2026Review
- Deep learning segmentation of paediatric brain tumours using diffusion-weighted MRI: towards an early,Brain communications · 2026Article
- Prognostic value of temporal muscle thickness in pediatric medulloblastoma patients aged 3-12 years.Journal of neuro-oncology · 2025Article
- Segmentation-free pretherapeutic assessment of BRAF-status in pediatric low-grade gliomas.Communications medicine · 2025Article
- Fine-tuned ResNet34 for efficient brain tumor classification.Scientific reports · 2025Article
- Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Pineal gland seminoma: unusual localisation investigated through a case report and a literature review.Ecancermedicalscience · 2025Article
- Seizures in brain tumor hospitalizations in the United States.Frontiers in neurology · 2025Article
- Review
- Incidental brain tumor findings in children: prevalence, natural history, management, controversies, challenges, and dilemmas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Article
- Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The clinical difference between brain tumors in adults and children is striking. Compared with adults, pediatric tumor types (mostly glial and neuronal) are more sensitive to adjuvant irradiation and chemotherapy. Pediatric tumors more often require craniospinal irradiation based on their propensity to disseminate within the neuraxis. The spectrum of side effects is broader in the child based on age and extent of treatment: radiation therapy brings increased risk of severe long-term sequelae affecting neurologic, endocrine, and cognitive function. In this review of glioma, ependymoma, and medulloblastoma, we highlight the differences between adults and children, including the higher incidence of spinal cord ependymoma and supratentorial high-grade glioma in the adult and a higher incidence of medulloblastoma in the child. With the exception of completely resected low-grade glioma, radiation therapy remains a standard of care for most patients. In some settings, the radiation oncologist should suggest further surgery or additional adjuvant therapy in an effort to optimize local tumor control. An effort is underway to better characterize adult and pediatric brain tumors biologically with an emphasis on improving our understanding of tumor genesis, malignant transformation, and some of the similarities and differences between tumor types and their response to conventional therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.