Evidence map›Paper›PMID 19959003›Full record

ArticleNeuroimaging clinics of North America2009

Advanced MRI: translation from animal to human in brain tumor research.

Bradford A Moffat, Craig J Galbán, Alnawaz Rehemtulla

Open access · greenAbstract read
In one paragraph

Article in Neuroimaging clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Bradford A MoffatDepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia. brad.moffat@mh.org.au
Craig J Galbán
Alnawaz Rehemtulla
University of Michigan–Ann Arbor · USThe Royal Melbourne Hospital · AU

Funding

QUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2001 to 2017
$31.9M
Small Animal Imaging CoreP50CA093990 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2002 to 2012
$19.0M
Michigan Small Animal Imaging Resource (MSAIR)U24CA083099 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2007 to 2008
$1.3M
NOVEL ENZYME/PRODRUG STRATEGY FOR CANCER GENE THERAPYR29CA073904 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REHEMTULLA, ALNAWAZ · 1997 to 2001
$203k
NCI NIH HHS P01 CA085878NCI NIH HHS P01CA085878NCI NIH HHS P50 CA093990NCI NIH HHS P50CA093990NCI NIH HHS R29 CA073904NCI NIH HHS U24 CA083099NCI NIH HHS U24CA083099
6 · The paper itself

Abstract

Advanced magnetic resonance imaging (MRI) techniques, such as magnetic resonance spectroscopy, diffusion MRI, and perfusion MRI, allow for a diverse range of multidimensional information regarding brain tumor physiology to be obtained in addition to the traditional anatomic images. Although it is well documented that MRI of rodent brain tumor models plays an important role in the basic research and drug discovery process of new brain tumor therapies, the role that animal models have played in translating these methodologies is rarely discussed in such articles. Even in consensus reports outlining the pathway to validation of these techniques, the use of animal models is given scant regard. This is despite that the use of rodent cancer models to test advanced MRI techniques predates and was integral to the development of clinical MRI. This article highlights just how integral preclinical imaging is to the discovery, development, and validation of advanced MRI techniques for imaging brain neoplasms.

Indexed as

Disease Models, AnimalAnimalsBiomarkers, TumorBrain NeoplasmsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyTranslational Research, BiomedicalBiomarkers, Tumor

Identifiers

PMID19959003
PMCPMC4256947
OpenAlexW2044402212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.