ArticleNanomedicine (London, England)2009
Characterization of biofilm formed by human-derived nanoparticles.
Article in Nanomedicine (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Morphomolecular Characterization of Serum Nanovesicles From Microbiomes Differentiates Stable and Infarcted Atherosclerotic Patients.Frontiers in cardiovascular medicine · 2021Article
- Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.International journal of nanomedicine · 2014Article
- Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.Nanoscale research letters · 2014Article
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- Microvesicles at the crossroads between infection and cardiovascular diseases.Journal of cardiovascular pharmacology · 2012Review
- Key role of alkaline phosphatase in the development of human-derived nanoparticles in vitro.Acta biomaterialia · 2011Article
- Proteomic evaluation of biological nanoparticles isolated from human kidney stones and calcified arteries.Acta biomaterialia · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
aimMicrobial biofilm matrix contains polysaccharides and proteins and can require extracellular nucleic acids for initial formation. Experiments were designed to identify infectious pathogens in human aneurysms and to characterize biofilm formed by calcified human arterial-derived nanoparticles. MATERIALS &
methodA total of 26 different microbial pathogens were isolated from 48 inflammatory aneurysms. Consistent amounts (0.49 McFarland units) of nanoparticles derived from similar tissue were seeded into 24-well plates and cultured for 21 days in the absence (control) or presence of RNase, tetracycline or gentamicin.
resultsControl biofilm developed within 14 days, as detected by concanavalin A and BacLight Green staining. The formation of biofilm in wells treated with RNase was not different from the control; however, gentamicin partially inhibited and tetracycline completely inhibited biofilm formation. Therefore, nanoparticle biofilm retains some characteristics of conventional bacterial biofilm and requires protein-calcium interactions, although extracellular RNA is not required.
conclusionThis model system may also allow study of nanosized vesicles derived from donor tissue, including any microbes present, and could provide a useful tool for in vitro investigation of nanoparticle biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.