Trial reportJournal of gastroenterology2010
Effect of exclusive enteral nutrition on bone turnover in children with Crohn's disease.
Trial report in Journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Nutrition in Pediatric Inflammatory Bowel Disease: From Etiology to Treatment. A Systematic Review.Nutrients · 2016Pooled it
- Skeletal health of children and adolescents with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2011Guideline
- Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease.Intestinal research · 2025Review
- Review
- Bone Health in Paediatric Inflammatory Bowel Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review.Clinical and experimental gastroenterology · 2025Review
- Considerations in Paediatric and Adolescent Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2024Review
- The Role of Vitamin D and Vitamin D Receptor Gene Polymorphisms in the Course of Inflammatory Bowel Disease in Children.Nutrients · 2024Article
- Review
- Diet, Sun, Physical Activity and Vitamin D Status in Children with Inflammatory Bowel Disease.Nutrients · 2022Article
- Diet as therapeutic intervention in Crohn's disease.Przeglad gastroenterologiczny · 2022Review
- Nutritional Treatment in Crohn's Disease.Nutrients · 2021Review
- Dietary Management in Pediatric Patients with Crohn's Disease.Nutrients · 2021Review
- Role of diet and nutrition in inflammatory bowel disease.World journal of experimental medicine · 2021Review
- EEN Yesterday and Today … CDED Today and Tomorrow.Nutrients · 2020Review
- Recent advances in understanding and managing pediatric inflammatory bowel disease.F1000Research · 2019Review
- The impact of exclusive enteral nutrition on the intestinal microbiota in inflammatory bowel disease.AIMS microbiology · 2018Review
- Colitis, independent of macronutrient intake, compromises bone structure and strength in growing piglets.Pediatric research · 2016Article
- Time to Relapse in Children with Crohn's Disease Treated with Azathioprine and Nutritional Therapy or Corticosteroids.Digestive diseases and sciences · 2016Article
- Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients.International journal of molecular sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor bone acquisition and increased fracture risk are significant complications associated with Crohn's disease (CD). The aim of this study was to determine the effects of 8 weeks of exclusive enteral nutrition (EEN) therapy upon markers of bone turnover in children with newly diagnosed CD.
methodsTwenty-three children with newly diagnosed CD and 20 controls (without CD) were enrolled. Children with CD were treated with 8 weeks of EEN. Inflammatory markers [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, platelets], nutritional markers (height, weight), and bone markers [C-terminal telopeptides of Type-1 collagen (CTX) and bone specific alkaline phosphatase (BAP)] were measured prior to and following therapy.
resultsAt diagnosis, children with CD had elevated serum CTX (2.967 +/- 0.881 ng/ml) compared to controls (2.059 +/- 0.568 ng/ml; P = 0.0003). Following the period of EEN, CTX levels fell significantly (2.260 +/- 0.547 ng/ml; P = 0.002), while serum BAP levels (51.24 +/- 31.31 microg/L at diagnosis; control serum BAP = 66.80 +/- 23.23 microg/L; P = 0.07) increased significantly (64.82 +/- 30.51 microg/L; P = 0.02), with both normalizing to control levels.
conclusionsAs well as reducing inflammation, decreasing disease activity, and improving nutrition in children with newly diagnosed CD, EEN therapy also normalized serum markers of bone turnover, suggesting an improvement in bone health. Further investigations of short- and long-term effects of EEN on bone density and overall bone health are now required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.