ArticleJournal of neurology2010
Impairment in motor reprogramming in Friedreich ataxia reflecting possible cerebellar dysfunction.
Article in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The cognitive profile of Friedreich ataxia: a systematic review and meta-analysis.BMC neurology · 2022Pooled it
- Utilisation of advance motor information is impaired in Friedreich ataxia.Cerebellum (London, England) · 2011Trial
- Clinical and cognitive assessment in Friedreich ataxia clinical trials: a review.Frontiers in neurology · 2025Review
- Neuro-Ophthalmological Findings in Friedreich's Ataxia.Journal of personalized medicine · 2021Review
- Emotion Recognition and Psychological Comorbidity in Friedreich's Ataxia.Cerebellum (London, England) · 2018Article
- Measuring Inhibition and Cognitive Flexibility in Friedreich Ataxia.Cerebellum (London, England) · 2017Article
- Fronto-cerebellar dysfunction and dysconnectivity underlying cognition in friedreich ataxia: The IMAGE-FRDA study.Human brain mapping · 2016Article
- Cognitive deficits in Friedreich ataxia correlate with micro-structural changes in dentatorubral tract.Cerebellum (London, England) · 2014Article
- Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia.Journal of neurology · 2013Article
- Cognition in Friedreich ataxia.Cerebellum (London, England) · 2012Article
- Unanswered questions in Friedreich ataxia.Journal of child neurology · 2012Review
- Clinical features of Friedreich ataxia.Journal of child neurology · 2012Review
- Neurodegeneration in friedreich's ataxia is associated with a mixed activation pattern of the brain. A fMRI study.Human brain mapping · 2012Article
- A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype.Neurogenetics · 2011Article
- Superior cerebellar peduncle atrophy in Friedreich's ataxia correlates with disease symptoms.Cerebellum (London, England) · 2011Article
- Ocular motor fixation deficits in Friedreich ataxia.Cerebellum (London, England) · 2010Article
- Depressive symptoms in Friedreich ataxia.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellar and spinocerebellar dysfunction seen in Friedreich ataxia (FRDA) has known effects on motor function. Recently, it was suggested that people with FRDA may also have impairment in motor planning, either because of cortical pathology or because of cerebello-cortical projections. Fifteen adults with FRDA and 15 matched controls completed a task requiring reciprocating movements between two buttons on a tapping board. Occasionally there was one of three "oddball" stimuli requiring reprogramming of movement. These were change in (1) direction, (2) extent or (3) direction and extent. We hypothesized that people with FRDA would have prolonged movement times due to their movement disorder, and that changes in preparation time would be affected in a way similar to controls, unless there was impairment in motor planning in FRDA. Movement execution and, to a lesser degree, movement preparation were impaired in individuals with FRDA. We argue this points to disturbed cortical function. There was a significant negative correlation between age of onset and all three reprogramming conditions, suggesting an impact of FRDA on developing motor planning. Future studies will be required to establish whether this dysfunction is due to cerebellar impairment interrupting cerebro-ponto-cerebello-thalamo-cerebral loops, primary cortical pathology or a combination of the two.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.