ArticleInflammation2010
Therapeutic effect of recombinant human catalase on H1N1 influenza-induced pneumonia in mice.
Article in Inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection.Antioxidants (Basel, Switzerland) · 2023Article
- The past, present, and future of enzyme-based therapies.Drug discovery today · 2022Review
- Extremophilic Oxidoreductases for the Industry: Five Successful Examples With Promising Projections.Frontiers in bioengineering and biotechnology · 2021Review
- Article
- SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?Oxidative medicine and cellular longevity · 2020Review
- Redox Biology of Respiratory Viral Infections.Viruses · 2018Review
- Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways.PloS one · 2018Article
- Catalase ameliorates diabetes-induced cardiac injury through reduced p65/RelA- mediated transcription of BECN1.Journal of cellular and molecular medicine · 2017Article
- The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice.Physiological reports · 2015Article
- Clinical pharmacokinetics of inhaled antimicrobials.Clinical pharmacokinetics · 2015Review
- Qiangzhi decoction protects mice from influenza A pneumonia through inhibition of inflammatory cytokine storm.Chinese journal of integrative medicine · 2015Article
- Respiratory Viral Infections and Subversion of Cellular Antioxidant Defenses.Journal of pharmacogenomics & pharmacoproteomics · 2014Article
- Ability of recombinant human catalase to suppress inflammation of the murine lung induced by influenza A.Inflammation · 2014Article
- Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice.Frontiers in immunology · 2014Article
- PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice.Applied microbiology and biotechnology · 2013Article
- Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate.Medical microbiology and immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) are believed to play a key role in the induction of lung damage caused by pneumonia and therapeutic agents that could effectively scavenge ROS may prevent or reduce the deleterious effects of influenza-induced pneumonia. In this study, we first demonstrated that human catalase could attenuate acute oxidative injury in lung tissues following influenza-induced pneumonia. Mice were infected with influenza virus H1N1 (FM1 strain) and treated with recombinant human catalase (50,000 U/kg) by inhalation. The survival time and survival rates of H1N1 induced pneumonia mice were increased by treatment with recombinant human catalase. Protective efficacy of catalase was also observed in lung histology, anti-oxidant parameters, pulmonary pathology and influenza viral titer in lungs in mice. These observations were associated with increased serum superoxide and hydroxyl radical anion scavenging capacities. This study strongly indicated that recombinant catalase might be a potential therapy for H1N1 influenza-induced pneumonia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.