ArticlePLoS biology2009
AGAMOUS controls GIANT KILLER, a multifunctional chromatin modifier in reproductive organ patterning and differentiation.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Meta-analyses of microarrays of Arabidopsis asymmetric leaves1 (as1), as2 and their modifying mutants reveal a critical role for the ETT pathway in stabilization of adaxial-abaxial patterning and cell division during leaf development.Plant & cell physiology · 2013Pooled it
- Genome-wide evolutionary characterization and expression analysis of the AT-HOOK MOTIF CONTAINING NUCLEAR LOCALIZED gene family in Brachypodium distachyon.G3 (Bethesda, Md.) · 2026Article
- Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14.Nature communications · 2025Article
- The Role of CRABS CLAW Transcription Factor in Floral Organ Development in Plants.International journal of molecular sciences · 2025Review
- AHL26, an AT-hook gene, negatively regulates hypocotyl growth and flowering time in Arabidopsis thaliana.BMC plant biology · 2025Article
- Genome-wide analysis of radishFrontiers in plant science · 2024Article
- AGAMOUS regulates various target genes via cell cycle-coupled H3K27me3 dilution in floral meristems and stamens.The Plant cell · 2023Article
- Overexpression of AHL proteins enhances root hair production by altering the transcription of RHD6-downstream genes.Plant direct · 2023Article
- Widely conserved AHL transcription factors are essential for NCR gene expression and nodule development in Medicago.Nature plants · 2023Article
- A model worker: Multifaceted modulation of AUXIN RESPONSE FACTOR3 orchestrates plant reproductive phases.Frontiers in plant science · 2023Review
- miR156-independent repression of the ageing pathway by longevity-promoting AHL proteins in Arabidopsis.The New phytologist · 2022Article
- SUPPRESSOR OF PHYTOCHROME B-4 #3 reduces the expression of PIF-activated genes and increases expression of growth repressors to regulate hypocotyl elongation in short days.BMC plant biology · 2022Article
- miR778 mediates gene expression, histone modification, and DNA methylation during cyst nematode parasitism.Plant physiology · 2022Article
- Transcription Factor Action Orchestrates the Complex Expression Pattern of CRABS CLAW in Arabidopsis.Genes · 2021Article
- An Arabidopsis AT-hook motif nuclear protein mediates somatic embryogenesis and coinciding genome duplication.Nature communications · 2021Article
- Insights Into the Molecular Evolution of AT-Hook Motif Nuclear Localization Genes inFrontiers in plant science · 2021Article
- Genome biology of the paleotetraploid perennial biomass crop Miscanthus.Nature communications · 2020Article
- Transcriptome and epigenome analyses of vernalization in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2020Article
- Article
- A suppressor of axillary meristem maturation promotes longevity in flowering plants.Nature plants · 2020Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The Arabidopsis homeotic protein AGAMOUS (AG), a MADS domain transcription factor, specifies reproductive organ identity during flower development. Using a binding assay and expression analysis, we identified a direct target of AG, GIANT KILLER (GIK), which fine-tunes the expression of multiple genes downstream of AG. The GIK protein contains an AT-hook DNA binding motif that is widely found in chromosomal proteins and that binds to nuclear matrix attachment regions of DNA elements. Overexpression and loss of function of GIK cause wide-ranging defects in patterning and differentiation of reproductive organs. GIK directly regulates the expression of several key transcriptional regulators, including ETTIN/AUXIN RESPONSE FACTOR 3 (ETT/ARF3) that patterns the gynoecium, by binding to the matrix attachment regions of target promoters. Overexpression of GIK causes a swift and dynamic change in repressive histone modification in the ETT promoter. We propose that GIK acts as a molecular node downstream of the homeotic protein AG, regulating patterning and differentiation of reproductive organs through chromatin organization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.