ArticlePLoS genetics2009
Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in theeLife · 2023Article
- Article
- Development and Function of theGenetics · 2018Review
- An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity.PLoS genetics · 2018Article
- Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection UsingJournal of experimental neuroscience · 2018Review
- THEMIS: Two Models, Different Thresholds.Trends in immunology · 2017Review
- Article
- Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration.Cell reports · 2015Article
- Outside-in signaling--a brief review of GPCR signaling with a focus on the Drosophila GPCR family.Journal of cell science · 2015Review
- Epidermal growth factor signalling controls myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis.PLoS biology · 2014Article
- Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.PLoS genetics · 2014Article
- High-NaCl perception in Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.Cell and tissue research · 2013Review
- Tubulogenesis.Development (Cambridge, England) · 2013Review
- Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.Development (Cambridge, England) · 2013Article
- The secreted AdamTS-A metalloprotease is required for collective cell migration.Development (Cambridge, England) · 2013Article
- The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2.Development (Cambridge, England) · 2013Article
- Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila.Nature cell biology · 2012Article
- Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.Nature cell biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Epithelial tubes are the functional units of many organs, and proper tube geometry is crucial for organ function. Here, we characterize serrano (sano), a novel cytoplasmic protein that is apically enriched in several tube-forming epithelia in Drosophila, including the tracheal system. Loss of sano results in elongated tracheae, whereas Sano overexpression causes shortened tracheae with reduced apical boundaries. Sano overexpression during larval and pupal stages causes planar cell polarity (PCP) defects in several adult tissues. In Sano-overexpressing pupal wing cells, core PCP proteins are mislocalized and prehairs are misoriented; sano loss or overexpression in the eye disrupts ommatidial polarity and rotation. Importantly, Sano binds the PCP regulator Dishevelled (Dsh), and loss or ectopic expression of many known PCP proteins in the trachea gives rise to similar defects observed with loss or gain of sano, revealing a previously unrecognized role for PCP pathway components in tube size control.
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