ArticlePloS one2009
Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
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- Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.Nature communications · 2022Article
- Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock.Developmental biology · 2022Article
- Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.PLoS genetics · 2021Review
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- Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinoma.BMC cancer · 2019Article
- Combined GWAS and 'guilt by association'-based prioritization analysis identifies functional candidate genes for body size in sheep.Genetics, selection, evolution : GSE · 2017Article
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- Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition.PLoS computational biology · 2014Article
- From dynamic expression patterns to boundary formation in the presomitic mesoderm.PLoS computational biology · 2012Article
- Golgi during development.Cold Spring Harbor perspectives in biology · 2011Review
- Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.Developmental biology · 2011Article
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate segmentation is regulated by the "segmentation clock", which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM). One such gene is Lunatic fringe (Lfng), which encodes a modifier of Notch signalling, and which is also expressed in a stripe at the cranial end of the PSM, adjacent to the newly forming somite border. We have investigated the functional requirements for these modes of Lfng expression during somitogenesis by generating mice in which Lfng is expressed in the cranial stripe but strongly reduced in the caudal PSM, and find that requirements for Lfng activity alter during axial growth. Formation of cervical, thoracic and lumbar somites/vertebrae, but not sacral and adjacent tail somites/vertebrae, depends on caudal, cyclic Lfng expression. Indeed, the sacral region segments normally in the complete absence of Lfng and shows a reduced requirement for another oscillating gene, Hes7, indicating that the architecture of the clock alters as segmentation progresses. We present evidence that Lfng controls dorsal-ventral axis specification in the tail, and also suggest that Lfng controls the expression or activity of a long-range signal that regulates axial extension.
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