ArticlePloS one2009
BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Synergistic Reinforcement Learning by Cooperation of the Cerebellum and Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy.Frontiers in cellular neuroscience · 2022Article
- Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.PLoS computational biology · 2020Article
- Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat.Frontiers in systems neuroscience · 2020Article
- Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6.Brain communications · 2020Article
- Regulation of BK Channels by Beta and Gamma Subunits.Annual review of physiology · 2019Review
- Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD.Scientific reports · 2018Article
- Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.Cell reports · 2017Article
- Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum.Frontiers in cellular neuroscience · 2017Article
- Cerebellar Synaptic Plasticity and the Credit Assignment Problem.Cerebellum (London, England) · 2016Review
- Oscillations, Timing, Plasticity, and Learning in the Cerebellum.Cerebellum (London, England) · 2016Review
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- In vivo analysis of Purkinje cell firing properties during postnatal mouse development.Journal of neurophysiology · 2015Article
- Emergence of a 600-Hz buzz UP state Purkinje cell firing in alert mice.Neuroscience · 2014Article
- Neuronal oscillations in Golgi cells and Purkinje cells are accompanied by decreases in Shannon information entropy.Cerebellum (London, England) · 2014Article
- Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance.Cerebellum (London, England) · 2013Article
- Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Translational approach to behavioral learning: lessons from cerebellar plasticity.Neural plasticity · 2013Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural activity- and calcium-mediated membrane properties of these cells are expected to provide important insights into both intrinsic and network physiology of the cerebellum. We studied the electrophysiological behavior of Purkinje cells in genetically engineered alert mice that do not express BK calcium-activated potassium channels and in wild-type mice with pharmacological BK inactivation. We confirmed BK expression in Purkinje cells and also demonstrated it in Golgi cells. We demonstrated that either genetic or pharmacological BK inactivation leads to ataxia and to the emergence of a beta oscillatory field potential in the cerebellar cortex. This oscillation is correlated with enhanced rhythmicity and synchronicity of both Purkinje and Golgi cells. We hypothesize that the temporal coding modification of the spike firing of both Purkinje and Golgi cells leads to the pharmacologically or genetically induced ataxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.